Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella

We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella-zoster virus with fatal outcome. The index case patient, nursed in source isolation, developed disseminated zoster with rash present for 1 day before being transferred to the intensive care unit...

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Detalles Bibliográficos
Autores principales: Depledge, Daniel P., Brown, Julianne, Macanovic, Jasna, Underhill, Gill, Breuer, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079377/
https://www.ncbi.nlm.nih.gov/pubmed/27571904
http://dx.doi.org/10.1093/infdis/jiw398
Descripción
Sumario:We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella-zoster virus with fatal outcome. The index case patient, nursed in source isolation, developed disseminated zoster with rash present for 1 day before being transferred to the intensive care unit (ICU). Two patients who had received renal transplants while inpatients in an adjacent ward developed chickenpox and 1 died; neither patient had direct contact with the index patient.

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