Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella

We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella-zoster virus with fatal outcome. The index case patient, nursed in source isolation, developed disseminated zoster with rash present for 1 day before being transferred to the intensive care unit...

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Detalles Bibliográficos
Autores principales: Depledge, Daniel P., Brown, Julianne, Macanovic, Jasna, Underhill, Gill, Breuer, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079377/
https://www.ncbi.nlm.nih.gov/pubmed/27571904
http://dx.doi.org/10.1093/infdis/jiw398
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author Depledge, Daniel P.
Brown, Julianne
Macanovic, Jasna
Underhill, Gill
Breuer, Judith
author_facet Depledge, Daniel P.
Brown, Julianne
Macanovic, Jasna
Underhill, Gill
Breuer, Judith
author_sort Depledge, Daniel P.
collection PubMed
description We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella-zoster virus with fatal outcome. The index case patient, nursed in source isolation, developed disseminated zoster with rash present for 1 day before being transferred to the intensive care unit (ICU). Two patients who had received renal transplants while inpatients in an adjacent ward developed chickenpox and 1 died; neither patient had direct contact with the index patient.
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spelling pubmed-50793772016-10-26 Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella Depledge, Daniel P. Brown, Julianne Macanovic, Jasna Underhill, Gill Breuer, Judith J Infect Dis Major Articles and Brief Reports We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella-zoster virus with fatal outcome. The index case patient, nursed in source isolation, developed disseminated zoster with rash present for 1 day before being transferred to the intensive care unit (ICU). Two patients who had received renal transplants while inpatients in an adjacent ward developed chickenpox and 1 died; neither patient had direct contact with the index patient. Oxford University Press 2016-11-01 2016-08-28 /pmc/articles/PMC5079377/ /pubmed/27571904 http://dx.doi.org/10.1093/infdis/jiw398 Text en © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Depledge, Daniel P.
Brown, Julianne
Macanovic, Jasna
Underhill, Gill
Breuer, Judith
Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella
title Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella
title_full Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella
title_fullStr Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella
title_full_unstemmed Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella
title_short Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella
title_sort viral genome sequencing proves nosocomial transmission of fatal varicella
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079377/
https://www.ncbi.nlm.nih.gov/pubmed/27571904
http://dx.doi.org/10.1093/infdis/jiw398
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