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Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses
Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic po...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079747/ https://www.ncbi.nlm.nih.gov/pubmed/27780032 http://dx.doi.org/10.7554/eLife.17977 |
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author | Vyleta, Nicholas P Borges-Merjane, Carolina Jonas, Peter |
author_facet | Vyleta, Nicholas P Borges-Merjane, Carolina Jonas, Peter |
author_sort | Vyleta, Nicholas P |
collection | PubMed |
description | Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic potentials (EPSPs) trigger spikes in CA3 neurons remains unknown. Mossy fiber synapses exhibit both pronounced short-term facilitation and uniquely large post-tetanic potentiation (PTP). We tested whether PTP could convert mossy fiber synapses from subdetonator into detonator mode, using a recently developed method to selectively and noninvasively stimulate individual presynaptic terminals in rat brain slices. Unitary EPSPs failed to initiate a spike in CA3 neurons under control conditions, but reliably discharged them after induction of presynaptic short-term plasticity. Remarkably, PTP switched mossy fiber synapses into full detonators for tens of seconds. Plasticity-dependent detonation may be critical for efficient coding, storage, and recall of information in the granule cell–CA3 cell network. DOI: http://dx.doi.org/10.7554/eLife.17977.001 |
format | Online Article Text |
id | pubmed-5079747 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-50797472016-10-26 Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses Vyleta, Nicholas P Borges-Merjane, Carolina Jonas, Peter eLife Neuroscience Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic potentials (EPSPs) trigger spikes in CA3 neurons remains unknown. Mossy fiber synapses exhibit both pronounced short-term facilitation and uniquely large post-tetanic potentiation (PTP). We tested whether PTP could convert mossy fiber synapses from subdetonator into detonator mode, using a recently developed method to selectively and noninvasively stimulate individual presynaptic terminals in rat brain slices. Unitary EPSPs failed to initiate a spike in CA3 neurons under control conditions, but reliably discharged them after induction of presynaptic short-term plasticity. Remarkably, PTP switched mossy fiber synapses into full detonators for tens of seconds. Plasticity-dependent detonation may be critical for efficient coding, storage, and recall of information in the granule cell–CA3 cell network. DOI: http://dx.doi.org/10.7554/eLife.17977.001 eLife Sciences Publications, Ltd 2016-10-25 /pmc/articles/PMC5079747/ /pubmed/27780032 http://dx.doi.org/10.7554/eLife.17977 Text en © 2016, Vyleta et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Vyleta, Nicholas P Borges-Merjane, Carolina Jonas, Peter Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses |
title | Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses |
title_full | Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses |
title_fullStr | Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses |
title_full_unstemmed | Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses |
title_short | Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses |
title_sort | plasticity-dependent, full detonation at hippocampal mossy fiber–ca3 pyramidal neuron synapses |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079747/ https://www.ncbi.nlm.nih.gov/pubmed/27780032 http://dx.doi.org/10.7554/eLife.17977 |
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