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Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses

Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic po...

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Detalles Bibliográficos
Autores principales: Vyleta, Nicholas P, Borges-Merjane, Carolina, Jonas, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079747/
https://www.ncbi.nlm.nih.gov/pubmed/27780032
http://dx.doi.org/10.7554/eLife.17977
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author Vyleta, Nicholas P
Borges-Merjane, Carolina
Jonas, Peter
author_facet Vyleta, Nicholas P
Borges-Merjane, Carolina
Jonas, Peter
author_sort Vyleta, Nicholas P
collection PubMed
description Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic potentials (EPSPs) trigger spikes in CA3 neurons remains unknown. Mossy fiber synapses exhibit both pronounced short-term facilitation and uniquely large post-tetanic potentiation (PTP). We tested whether PTP could convert mossy fiber synapses from subdetonator into detonator mode, using a recently developed method to selectively and noninvasively stimulate individual presynaptic terminals in rat brain slices. Unitary EPSPs failed to initiate a spike in CA3 neurons under control conditions, but reliably discharged them after induction of presynaptic short-term plasticity. Remarkably, PTP switched mossy fiber synapses into full detonators for tens of seconds. Plasticity-dependent detonation may be critical for efficient coding, storage, and recall of information in the granule cell–CA3 cell network. DOI: http://dx.doi.org/10.7554/eLife.17977.001
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spelling pubmed-50797472016-10-26 Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses Vyleta, Nicholas P Borges-Merjane, Carolina Jonas, Peter eLife Neuroscience Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic potentials (EPSPs) trigger spikes in CA3 neurons remains unknown. Mossy fiber synapses exhibit both pronounced short-term facilitation and uniquely large post-tetanic potentiation (PTP). We tested whether PTP could convert mossy fiber synapses from subdetonator into detonator mode, using a recently developed method to selectively and noninvasively stimulate individual presynaptic terminals in rat brain slices. Unitary EPSPs failed to initiate a spike in CA3 neurons under control conditions, but reliably discharged them after induction of presynaptic short-term plasticity. Remarkably, PTP switched mossy fiber synapses into full detonators for tens of seconds. Plasticity-dependent detonation may be critical for efficient coding, storage, and recall of information in the granule cell–CA3 cell network. DOI: http://dx.doi.org/10.7554/eLife.17977.001 eLife Sciences Publications, Ltd 2016-10-25 /pmc/articles/PMC5079747/ /pubmed/27780032 http://dx.doi.org/10.7554/eLife.17977 Text en © 2016, Vyleta et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Vyleta, Nicholas P
Borges-Merjane, Carolina
Jonas, Peter
Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses
title Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses
title_full Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses
title_fullStr Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses
title_full_unstemmed Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses
title_short Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses
title_sort plasticity-dependent, full detonation at hippocampal mossy fiber–ca3 pyramidal neuron synapses
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079747/
https://www.ncbi.nlm.nih.gov/pubmed/27780032
http://dx.doi.org/10.7554/eLife.17977
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