Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata

ABSTRACT: Four hitherto unknown prenylated coumarins, namely 6″-O-β-d-apiofuranosylapterin (1), 4′-O-isobutyroylpeguangxienin (2), 6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin (3), and 6-hydroxycoumurrayin (4), were isolated from the ethanol extract of Heracleum stenopterum, Peucedanum praeruptorum,...

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Autores principales: Li, Xiang-Mei, Jiang, Xian-Jun, Yang, Ku, Wang, Li-Xia, Wen, Shi-Zhen, Wang, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080209/
https://www.ncbi.nlm.nih.gov/pubmed/27646268
http://dx.doi.org/10.1007/s13659-016-0107-5
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author Li, Xiang-Mei
Jiang, Xian-Jun
Yang, Ku
Wang, Li-Xia
Wen, Shi-Zhen
Wang, Fei
author_facet Li, Xiang-Mei
Jiang, Xian-Jun
Yang, Ku
Wang, Li-Xia
Wen, Shi-Zhen
Wang, Fei
author_sort Li, Xiang-Mei
collection PubMed
description ABSTRACT: Four hitherto unknown prenylated coumarins, namely 6″-O-β-d-apiofuranosylapterin (1), 4′-O-isobutyroylpeguangxienin (2), 6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin (3), and 6-hydroxycoumurrayin (4), were isolated from the ethanol extract of Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata, respectively. Their chemical structures were established on the basis of extensive spectroscopic analysis. Compound 2 exhibited in vitro cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480) with IC(50) values ranging from 15.9 to 23.2 μM. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-016-0107-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-50802092016-11-07 Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata Li, Xiang-Mei Jiang, Xian-Jun Yang, Ku Wang, Li-Xia Wen, Shi-Zhen Wang, Fei Nat Prod Bioprospect Original Article ABSTRACT: Four hitherto unknown prenylated coumarins, namely 6″-O-β-d-apiofuranosylapterin (1), 4′-O-isobutyroylpeguangxienin (2), 6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin (3), and 6-hydroxycoumurrayin (4), were isolated from the ethanol extract of Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata, respectively. Their chemical structures were established on the basis of extensive spectroscopic analysis. Compound 2 exhibited in vitro cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480) with IC(50) values ranging from 15.9 to 23.2 μM. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-016-0107-5) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-09-19 /pmc/articles/PMC5080209/ /pubmed/27646268 http://dx.doi.org/10.1007/s13659-016-0107-5 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Li, Xiang-Mei
Jiang, Xian-Jun
Yang, Ku
Wang, Li-Xia
Wen, Shi-Zhen
Wang, Fei
Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata
title Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata
title_full Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata
title_fullStr Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata
title_full_unstemmed Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata
title_short Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata
title_sort prenylated coumarins from heracleum stenopterum, peucedanum praeruptorum, clausena lansium, and murraya paniculata
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080209/
https://www.ncbi.nlm.nih.gov/pubmed/27646268
http://dx.doi.org/10.1007/s13659-016-0107-5
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