Lactam Triterpenoids from the Bark of Toona sinensis

Three new limonoid-type triterpenoids, namely toonasins A–C (1–3) with a rare lactam E ring, along with six known compounds (4–9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of...

Descripción completa

Detalles Bibliográficos
Autores principales: Meng, Qian-Qian, Peng, Xing-Rong, Lu, Shuang-Yang, Wan, Luo-Sheng, Wang, Xia, Dong, Jin-Run, Chu, Rui, Zhou, Lin, Li, Xiao-Nian, Qiu, Ming-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080210/
https://www.ncbi.nlm.nih.gov/pubmed/27757925
http://dx.doi.org/10.1007/s13659-016-0108-4
Descripción
Sumario:Three new limonoid-type triterpenoids, namely toonasins A–C (1–3) with a rare lactam E ring, along with six known compounds (4–9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of compound 1 was further characterized by X-ray crystallographic analyses. The isolated compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compounds 3 and 5 showed weak cytotoxicities. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-016-0108-4) contains supplementary material, which is available to authorized users.

Ejemplares similares