Lactam Triterpenoids from the Bark of Toona sinensis

Three new limonoid-type triterpenoids, namely toonasins A–C (1–3) with a rare lactam E ring, along with six known compounds (4–9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of...

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Autores principales: Meng, Qian-Qian, Peng, Xing-Rong, Lu, Shuang-Yang, Wan, Luo-Sheng, Wang, Xia, Dong, Jin-Run, Chu, Rui, Zhou, Lin, Li, Xiao-Nian, Qiu, Ming-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080210/
https://www.ncbi.nlm.nih.gov/pubmed/27757925
http://dx.doi.org/10.1007/s13659-016-0108-4
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author Meng, Qian-Qian
Peng, Xing-Rong
Lu, Shuang-Yang
Wan, Luo-Sheng
Wang, Xia
Dong, Jin-Run
Chu, Rui
Zhou, Lin
Li, Xiao-Nian
Qiu, Ming-Hua
author_facet Meng, Qian-Qian
Peng, Xing-Rong
Lu, Shuang-Yang
Wan, Luo-Sheng
Wang, Xia
Dong, Jin-Run
Chu, Rui
Zhou, Lin
Li, Xiao-Nian
Qiu, Ming-Hua
author_sort Meng, Qian-Qian
collection PubMed
description Three new limonoid-type triterpenoids, namely toonasins A–C (1–3) with a rare lactam E ring, along with six known compounds (4–9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of compound 1 was further characterized by X-ray crystallographic analyses. The isolated compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compounds 3 and 5 showed weak cytotoxicities. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-016-0108-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-50802102016-11-07 Lactam Triterpenoids from the Bark of Toona sinensis Meng, Qian-Qian Peng, Xing-Rong Lu, Shuang-Yang Wan, Luo-Sheng Wang, Xia Dong, Jin-Run Chu, Rui Zhou, Lin Li, Xiao-Nian Qiu, Ming-Hua Nat Prod Bioprospect Original Article Three new limonoid-type triterpenoids, namely toonasins A–C (1–3) with a rare lactam E ring, along with six known compounds (4–9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of compound 1 was further characterized by X-ray crystallographic analyses. The isolated compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compounds 3 and 5 showed weak cytotoxicities. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-016-0108-4) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-10-18 /pmc/articles/PMC5080210/ /pubmed/27757925 http://dx.doi.org/10.1007/s13659-016-0108-4 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Meng, Qian-Qian
Peng, Xing-Rong
Lu, Shuang-Yang
Wan, Luo-Sheng
Wang, Xia
Dong, Jin-Run
Chu, Rui
Zhou, Lin
Li, Xiao-Nian
Qiu, Ming-Hua
Lactam Triterpenoids from the Bark of Toona sinensis
title Lactam Triterpenoids from the Bark of Toona sinensis
title_full Lactam Triterpenoids from the Bark of Toona sinensis
title_fullStr Lactam Triterpenoids from the Bark of Toona sinensis
title_full_unstemmed Lactam Triterpenoids from the Bark of Toona sinensis
title_short Lactam Triterpenoids from the Bark of Toona sinensis
title_sort lactam triterpenoids from the bark of toona sinensis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080210/
https://www.ncbi.nlm.nih.gov/pubmed/27757925
http://dx.doi.org/10.1007/s13659-016-0108-4
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