Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa

ABSTRACT: Four new clerodane diterpenoids, tinosporols A–C (2–4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpe...

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Detalles Bibliográficos
Autores principales: Gao, Yuan, Niu, Yan-Fen, Wang, Fei, Hai, Ping, Wang, Fang, Fang, Yin-Dong, Xiong, Wen-Yong, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080211/
https://www.ncbi.nlm.nih.gov/pubmed/27752986
http://dx.doi.org/10.1007/s13659-016-0109-3
Descripción
Sumario:ABSTRACT: Four new clerodane diterpenoids, tinosporols A–C (2–4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-016-0109-3) contains supplementary material, which is available to authorized users.

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