Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa

ABSTRACT: Four new clerodane diterpenoids, tinosporols A–C (2–4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpe...

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Autores principales: Gao, Yuan, Niu, Yan-Fen, Wang, Fei, Hai, Ping, Wang, Fang, Fang, Yin-Dong, Xiong, Wen-Yong, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080211/
https://www.ncbi.nlm.nih.gov/pubmed/27752986
http://dx.doi.org/10.1007/s13659-016-0109-3
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author Gao, Yuan
Niu, Yan-Fen
Wang, Fei
Hai, Ping
Wang, Fang
Fang, Yin-Dong
Xiong, Wen-Yong
Liu, Ji-Kai
author_facet Gao, Yuan
Niu, Yan-Fen
Wang, Fei
Hai, Ping
Wang, Fang
Fang, Yin-Dong
Xiong, Wen-Yong
Liu, Ji-Kai
author_sort Gao, Yuan
collection PubMed
description ABSTRACT: Four new clerodane diterpenoids, tinosporols A–C (2–4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-016-0109-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-50802112016-11-07 Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa Gao, Yuan Niu, Yan-Fen Wang, Fei Hai, Ping Wang, Fang Fang, Yin-Dong Xiong, Wen-Yong Liu, Ji-Kai Nat Prod Bioprospect Original Article ABSTRACT: Four new clerodane diterpenoids, tinosporols A–C (2–4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-016-0109-3) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-10-17 /pmc/articles/PMC5080211/ /pubmed/27752986 http://dx.doi.org/10.1007/s13659-016-0109-3 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Gao, Yuan
Niu, Yan-Fen
Wang, Fei
Hai, Ping
Wang, Fang
Fang, Yin-Dong
Xiong, Wen-Yong
Liu, Ji-Kai
Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa
title Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa
title_full Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa
title_fullStr Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa
title_full_unstemmed Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa
title_short Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa
title_sort clerodane diterpenoids with anti-hyperglycemic activity from tinospora crispa
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080211/
https://www.ncbi.nlm.nih.gov/pubmed/27752986
http://dx.doi.org/10.1007/s13659-016-0109-3
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