Pharmacological Inhibition of Host Heme Oxygenase-1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes

Heme oxygenase-1 (HO-1) is a stress response antioxidant enzyme which catalyzes the degradation of heme released during inflammation. HO-1 expression is upregulated in both experimental and human Mycobacterium tuberculosis infection, and in patients it is a biomarker of active disease. Whether the e...

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Detalles Bibliográficos
Autores principales: Costa, Diego L., Namasivayam, Sivaranjani, Amaral, Eduardo P., Arora, Kriti, Chao, Alex, Mittereder, Lara R., Maiga, Mamoudou, Boshoff, Helena I., Barry, Clifton E., Goulding, Celia W., Andrade, Bruno B., Sher, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080384/
https://www.ncbi.nlm.nih.gov/pubmed/27795400
http://dx.doi.org/10.1128/mBio.01675-16

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