Compositional Dynamics: Defining the Fuzzy Cell

Proteomic studies find many proteins in unexpected cellular locations. Can functional components of organelles be distinguished from biochemical artefacts or misguided cellular sorting? The clue might reside in compositional changes that follow biological challenges and that can be decoded by machin...

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Detalles Bibliográficos
Autores principales: Kustatscher, Georg, Rappsilber, Juri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2016
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080450/
https://www.ncbi.nlm.nih.gov/pubmed/27651031
http://dx.doi.org/10.1016/j.tcb.2016.08.012
Descripción
Sumario:Proteomic studies find many proteins in unexpected cellular locations. Can functional components of organelles be distinguished from biochemical artefacts or misguided cellular sorting? The clue might reside in compositional changes that follow biological challenges and that can be decoded by machine learning.

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