Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney

The type-2 diabetes drug metformin has proven to have protective effects in several renal disease models. Here, we investigated the protective effects in a 3-day unilateral ureteral obstruction (3dUUO) mouse model. Compared with controls, ureteral obstructed animals displayed increased tubular damag...

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Detalles Bibliográficos
Autores principales: Christensen, Michael, Jensen, Jonas B., Jakobsen, Steen, Jessen, Niels, Frøkiær, Jørgen, Kemp, Bruce E., Marciszyn, Allison L., Li, Hui, Pastor-Soler, Núria M., Hallows, Kenneth R., Nørregaard, Rikke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080611/
https://www.ncbi.nlm.nih.gov/pubmed/27782167
http://dx.doi.org/10.1038/srep35952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080611/
https://www.ncbi.nlm.nih.gov/pubmed/27782167
http://dx.doi.org/10.1038/srep35952

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