Assessing the Impact of Tissue Target Concentration Data on Uncertainty in In Vivo Target Coverage Predictions

Understanding pharmacological target coverage is fundamental in drug discovery and development as it helps establish a sequence of research activities, from laboratory objectives to clinical doses. To this end, we evaluated the impact of tissue target concentration data on the level of confidence in...

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Detalles Bibliográficos
Autores principales: Tiwari, A, Luo, H, Chen, X, Singh, P, Bhattacharya, I, Jasper, P, Tolsma, JE, Jones, HM, Zutshi4, A, Abraham5, AK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080652/
https://www.ncbi.nlm.nih.gov/pubmed/27770597
http://dx.doi.org/10.1002/psp4.12126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080652/
https://www.ncbi.nlm.nih.gov/pubmed/27770597
http://dx.doi.org/10.1002/psp4.12126

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