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Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models

BACKGROUND: Autophagy is a bulk catabolic process that modulates tumorigenesis, therapeutic resistance, and dormancy. The tumor suppressor ARHI (DIRAS3) is a potent inducer of autophagy and its expression results in necroptotic cell death in vitro and tumor dormancy in vivo. ARHI is down-regulated o...

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Detalles Bibliográficos
Autores principales:	Ornelas, Argentina, McCullough, Christopher R., Lu, Zhen, Zacharias, Niki M., Kelderhouse, Lindsay E., Gray, Joshua, Yang, Hailing, Engel, Brian J., Wang, Yan, Mao, Weiqun, Sutton, Margie N., Bhattacharya, Pratip K., Bast, Robert C., Millward, Steven W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080741/ https://www.ncbi.nlm.nih.gov/pubmed/27784287 http://dx.doi.org/10.1186/s12885-016-2850-8

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