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Preoperative Nutritional Deficiency Is a Useful Predictor of Postoperative Outcome in Patients Undergoing Curative Resection for Gastric Cancer

BACKGROUND: Preoperative nutritional deficiency (ND) has been shown to be a valuable prognostic factor in urologic malignancies. We aimed to investigate the prognostic value of ND in patients with gastric cancer (GC). METHODS: A single-center cohort of 1026 GC patients undergoing curative resection...

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Autores principales: Liu, Xuechao, Xu, Pengfei, Qiu, Haibo, Xu, Dazhi, Li, Wei, Zhan, Youqing, Li, Yuanfang, Chen, Yingbo, Zhou, Zhiwei, Sun, Xiaowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080742/
https://www.ncbi.nlm.nih.gov/pubmed/27788388
http://dx.doi.org/10.1016/j.tranon.2016.09.008
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author Liu, Xuechao
Xu, Pengfei
Qiu, Haibo
Xu, Dazhi
Li, Wei
Zhan, Youqing
Li, Yuanfang
Chen, Yingbo
Zhou, Zhiwei
Sun, Xiaowei
author_facet Liu, Xuechao
Xu, Pengfei
Qiu, Haibo
Xu, Dazhi
Li, Wei
Zhan, Youqing
Li, Yuanfang
Chen, Yingbo
Zhou, Zhiwei
Sun, Xiaowei
author_sort Liu, Xuechao
collection PubMed
description BACKGROUND: Preoperative nutritional deficiency (ND) has been shown to be a valuable prognostic factor in urologic malignancies. We aimed to investigate the prognostic value of ND in patients with gastric cancer (GC). METHODS: A single-center cohort of 1026 GC patients undergoing curative resection between 2003 and 2012 was categorized to ND and nutritionally replete (NR) groups. Patients with body mass index <18.5 kg/m(2), preoperative albumin <35 g/l, or preoperative weight loss ≥5% of body weight were defined as ND. RESULTS: Of the 1026 patients included in the study, 585 (57.0%) were categorized as ND. Overall survival (OS) at 5 years was 68.5% for ND patients and 44.0% for NR patients (P < .001). Multivariate analysis revealed that ND was a significant predictor of OS (hazard ratio: 1.954; 95% confidence interval: 1.552-2.460; P < .001). In stage-stratified analysis, it was still independently associated with OS in tumor-nodes-metastasis stage II and III (P = .004 and P < .001, respectively). Of note, the prognostic significance of ND was still maintained when stratified by age, sex, anemia, and adjuvant chemotherapy (all Ps < .05). CONCLUSION: Preoperative ND is a novel predictor of outcome in GC, especially in stage II to III GC, and may help clinicians identify high-risk patients for proactive nutritional interventions.
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spelling pubmed-50807422016-11-04 Preoperative Nutritional Deficiency Is a Useful Predictor of Postoperative Outcome in Patients Undergoing Curative Resection for Gastric Cancer Liu, Xuechao Xu, Pengfei Qiu, Haibo Xu, Dazhi Li, Wei Zhan, Youqing Li, Yuanfang Chen, Yingbo Zhou, Zhiwei Sun, Xiaowei Transl Oncol Original article BACKGROUND: Preoperative nutritional deficiency (ND) has been shown to be a valuable prognostic factor in urologic malignancies. We aimed to investigate the prognostic value of ND in patients with gastric cancer (GC). METHODS: A single-center cohort of 1026 GC patients undergoing curative resection between 2003 and 2012 was categorized to ND and nutritionally replete (NR) groups. Patients with body mass index <18.5 kg/m(2), preoperative albumin <35 g/l, or preoperative weight loss ≥5% of body weight were defined as ND. RESULTS: Of the 1026 patients included in the study, 585 (57.0%) were categorized as ND. Overall survival (OS) at 5 years was 68.5% for ND patients and 44.0% for NR patients (P < .001). Multivariate analysis revealed that ND was a significant predictor of OS (hazard ratio: 1.954; 95% confidence interval: 1.552-2.460; P < .001). In stage-stratified analysis, it was still independently associated with OS in tumor-nodes-metastasis stage II and III (P = .004 and P < .001, respectively). Of note, the prognostic significance of ND was still maintained when stratified by age, sex, anemia, and adjuvant chemotherapy (all Ps < .05). CONCLUSION: Preoperative ND is a novel predictor of outcome in GC, especially in stage II to III GC, and may help clinicians identify high-risk patients for proactive nutritional interventions. Neoplasia Press 2016-10-24 /pmc/articles/PMC5080742/ /pubmed/27788388 http://dx.doi.org/10.1016/j.tranon.2016.09.008 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original article
Liu, Xuechao
Xu, Pengfei
Qiu, Haibo
Xu, Dazhi
Li, Wei
Zhan, Youqing
Li, Yuanfang
Chen, Yingbo
Zhou, Zhiwei
Sun, Xiaowei
Preoperative Nutritional Deficiency Is a Useful Predictor of Postoperative Outcome in Patients Undergoing Curative Resection for Gastric Cancer
title Preoperative Nutritional Deficiency Is a Useful Predictor of Postoperative Outcome in Patients Undergoing Curative Resection for Gastric Cancer
title_full Preoperative Nutritional Deficiency Is a Useful Predictor of Postoperative Outcome in Patients Undergoing Curative Resection for Gastric Cancer
title_fullStr Preoperative Nutritional Deficiency Is a Useful Predictor of Postoperative Outcome in Patients Undergoing Curative Resection for Gastric Cancer
title_full_unstemmed Preoperative Nutritional Deficiency Is a Useful Predictor of Postoperative Outcome in Patients Undergoing Curative Resection for Gastric Cancer
title_short Preoperative Nutritional Deficiency Is a Useful Predictor of Postoperative Outcome in Patients Undergoing Curative Resection for Gastric Cancer
title_sort preoperative nutritional deficiency is a useful predictor of postoperative outcome in patients undergoing curative resection for gastric cancer
topic Original article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080742/
https://www.ncbi.nlm.nih.gov/pubmed/27788388
http://dx.doi.org/10.1016/j.tranon.2016.09.008
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