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The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study
PURPOSE: The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL). MATERIALS AND METHODS: The study po...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Cancer Association
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080822/ https://www.ncbi.nlm.nih.gov/pubmed/26987394 http://dx.doi.org/10.4143/crt.2016.013 |
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author | So, Kyeong A Kim, Mi Jung Lee, Ki-Heon Lee, In-Ho Kim, Mi Kyung Lee, Yoo Kyung Hwang, Chang-Sun Jeong, Mi Seon Kee, Mee-Kyung Kang, Chun Cho, Chi Heum Kim, Seok Mo Hong, Sung Ran Kim, Ki Tae Lee, Won-Chul Park, Jong Sup Kim, Tae Jin |
author_facet | So, Kyeong A Kim, Mi Jung Lee, Ki-Heon Lee, In-Ho Kim, Mi Kyung Lee, Yoo Kyung Hwang, Chang-Sun Jeong, Mi Seon Kee, Mee-Kyung Kang, Chun Cho, Chi Heum Kim, Seok Mo Hong, Sung Ran Kim, Ki Tae Lee, Won-Chul Park, Jong Sup Kim, Tae Jin |
author_sort | So, Kyeong A |
collection | PubMed |
description | PURPOSE: The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL). MATERIALS AND METHODS: The study population was derived from the Korean HPV cohort (2010-2014). Women aged 20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled patients underwent cervical cytology and HPV DNA testing every 6 months. RESULTS: A total of 1,158 patients were enrolled. The 10 most common HPV types were HPV 16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%), 68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months. Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001). CONCLUSION: HPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and LSIL. HPV 58 was the second most common type, with a high progression rate of cervical cytology. |
format | Online Article Text |
id | pubmed-5080822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-50808222016-11-03 The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study So, Kyeong A Kim, Mi Jung Lee, Ki-Heon Lee, In-Ho Kim, Mi Kyung Lee, Yoo Kyung Hwang, Chang-Sun Jeong, Mi Seon Kee, Mee-Kyung Kang, Chun Cho, Chi Heum Kim, Seok Mo Hong, Sung Ran Kim, Ki Tae Lee, Won-Chul Park, Jong Sup Kim, Tae Jin Cancer Res Treat Original Article PURPOSE: The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL). MATERIALS AND METHODS: The study population was derived from the Korean HPV cohort (2010-2014). Women aged 20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled patients underwent cervical cytology and HPV DNA testing every 6 months. RESULTS: A total of 1,158 patients were enrolled. The 10 most common HPV types were HPV 16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%), 68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months. Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001). CONCLUSION: HPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and LSIL. HPV 58 was the second most common type, with a high progression rate of cervical cytology. Korean Cancer Association 2016-10 2016-03-09 /pmc/articles/PMC5080822/ /pubmed/26987394 http://dx.doi.org/10.4143/crt.2016.013 Text en Copyright © 2016 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article So, Kyeong A Kim, Mi Jung Lee, Ki-Heon Lee, In-Ho Kim, Mi Kyung Lee, Yoo Kyung Hwang, Chang-Sun Jeong, Mi Seon Kee, Mee-Kyung Kang, Chun Cho, Chi Heum Kim, Seok Mo Hong, Sung Ran Kim, Ki Tae Lee, Won-Chul Park, Jong Sup Kim, Tae Jin The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study |
title | The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study |
title_full | The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study |
title_fullStr | The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study |
title_full_unstemmed | The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study |
title_short | The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study |
title_sort | impact of high-risk hpv genotypes other than hpv 16/18 on the natural course of abnormal cervical cytology: a korean hpv cohort study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080822/ https://www.ncbi.nlm.nih.gov/pubmed/26987394 http://dx.doi.org/10.4143/crt.2016.013 |
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