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Predictors of Distant Metastasis after Radical Surgery Followed by Postoperative Radiotherapy with or without Chemotherapy for Oropharyngeal Cancer

PURPOSE: We investigated the prognostic factors for distant metastasis (DM) in patients with locally advanced oropharyngeal cancer (OPC) treated with surgery and adjuvant radiotherapy with or without concurrent chemotherapy. MATERIALS AND METHODS: Eighty-five patients treated between January 1995 an...

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Autores principales: Chung, Mi Joo, Kim, Yeon Sil, Kim, Ji Yoon, Lee, Yun Hee, Jang, Ji Hyun, Kang, Jin Hyoung, Yoo, Ie Ryung, Lee, Youn Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080823/
https://www.ncbi.nlm.nih.gov/pubmed/26987396
http://dx.doi.org/10.4143/crt.2015.379
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author Chung, Mi Joo
Kim, Yeon Sil
Kim, Ji Yoon
Lee, Yun Hee
Jang, Ji Hyun
Kang, Jin Hyoung
Yoo, Ie Ryung
Lee, Youn Soo
author_facet Chung, Mi Joo
Kim, Yeon Sil
Kim, Ji Yoon
Lee, Yun Hee
Jang, Ji Hyun
Kang, Jin Hyoung
Yoo, Ie Ryung
Lee, Youn Soo
author_sort Chung, Mi Joo
collection PubMed
description PURPOSE: We investigated the prognostic factors for distant metastasis (DM) in patients with locally advanced oropharyngeal cancer (OPC) treated with surgery and adjuvant radiotherapy with or without concurrent chemotherapy. MATERIALS AND METHODS: Eighty-five patients treated between January 1995 and August 2014 were evaluated retrospectively. Data regarding the pathological tumour and nodal status, human papillomavirus (HPV) status, treatment characteristics, and pretreatment maximum standardized uptake value (SUVmax) of 18-fluoro-2-deoxyglucose positron emission tomography–computed tomography scan ((18)F-FDG PET-CT) were evaluated, and their influence on DM and survival outcomes were analyzed. RESULTS: Median follow-up period was 48.0 months. Recurrence was observed in 20 patients, including locoregional recurrence and DM. DM was observed in 13 patients. A multivariate analysis confirmed that the presence of lymphovascular invasion (p=0.031), lower neck lymph node (LN) involvement (p=0.006), SUVmax ≥ 9.7 (p=0.014), and tumour size ≥ 3 cm (p=0.037) significantly affected DM. HPV status was not associated with DM. Perineural invasion (p=0.048), lower neck LNinvolvement (p=0.008), SUVmax ≥ 9.7 (p=0.019), and tumour size ≥ 3 cm (p=0.033) were also significant factors for the DM-free survival rate. CONCLUSION: Lower neck LN involvement, high SUVmax in pretreatment (18)F-FDG PET-CT, and large tumour size were predictive factors for DM in patients of OPC.
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spelling pubmed-50808232016-11-03 Predictors of Distant Metastasis after Radical Surgery Followed by Postoperative Radiotherapy with or without Chemotherapy for Oropharyngeal Cancer Chung, Mi Joo Kim, Yeon Sil Kim, Ji Yoon Lee, Yun Hee Jang, Ji Hyun Kang, Jin Hyoung Yoo, Ie Ryung Lee, Youn Soo Cancer Res Treat Original Article PURPOSE: We investigated the prognostic factors for distant metastasis (DM) in patients with locally advanced oropharyngeal cancer (OPC) treated with surgery and adjuvant radiotherapy with or without concurrent chemotherapy. MATERIALS AND METHODS: Eighty-five patients treated between January 1995 and August 2014 were evaluated retrospectively. Data regarding the pathological tumour and nodal status, human papillomavirus (HPV) status, treatment characteristics, and pretreatment maximum standardized uptake value (SUVmax) of 18-fluoro-2-deoxyglucose positron emission tomography–computed tomography scan ((18)F-FDG PET-CT) were evaluated, and their influence on DM and survival outcomes were analyzed. RESULTS: Median follow-up period was 48.0 months. Recurrence was observed in 20 patients, including locoregional recurrence and DM. DM was observed in 13 patients. A multivariate analysis confirmed that the presence of lymphovascular invasion (p=0.031), lower neck lymph node (LN) involvement (p=0.006), SUVmax ≥ 9.7 (p=0.014), and tumour size ≥ 3 cm (p=0.037) significantly affected DM. HPV status was not associated with DM. Perineural invasion (p=0.048), lower neck LNinvolvement (p=0.008), SUVmax ≥ 9.7 (p=0.019), and tumour size ≥ 3 cm (p=0.033) were also significant factors for the DM-free survival rate. CONCLUSION: Lower neck LN involvement, high SUVmax in pretreatment (18)F-FDG PET-CT, and large tumour size were predictive factors for DM in patients of OPC. Korean Cancer Association 2016-10 2016-03-03 /pmc/articles/PMC5080823/ /pubmed/26987396 http://dx.doi.org/10.4143/crt.2015.379 Text en Copyright © 2016 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chung, Mi Joo
Kim, Yeon Sil
Kim, Ji Yoon
Lee, Yun Hee
Jang, Ji Hyun
Kang, Jin Hyoung
Yoo, Ie Ryung
Lee, Youn Soo
Predictors of Distant Metastasis after Radical Surgery Followed by Postoperative Radiotherapy with or without Chemotherapy for Oropharyngeal Cancer
title Predictors of Distant Metastasis after Radical Surgery Followed by Postoperative Radiotherapy with or without Chemotherapy for Oropharyngeal Cancer
title_full Predictors of Distant Metastasis after Radical Surgery Followed by Postoperative Radiotherapy with or without Chemotherapy for Oropharyngeal Cancer
title_fullStr Predictors of Distant Metastasis after Radical Surgery Followed by Postoperative Radiotherapy with or without Chemotherapy for Oropharyngeal Cancer
title_full_unstemmed Predictors of Distant Metastasis after Radical Surgery Followed by Postoperative Radiotherapy with or without Chemotherapy for Oropharyngeal Cancer
title_short Predictors of Distant Metastasis after Radical Surgery Followed by Postoperative Radiotherapy with or without Chemotherapy for Oropharyngeal Cancer
title_sort predictors of distant metastasis after radical surgery followed by postoperative radiotherapy with or without chemotherapy for oropharyngeal cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080823/
https://www.ncbi.nlm.nih.gov/pubmed/26987396
http://dx.doi.org/10.4143/crt.2015.379
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