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The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders
Administration of oxytocin has been proposed as a treatment for the core symptoms of autism spectrum disorder (ASD), including social-communicative deficit. Previous clinical trials have investigated the efficacy and safety of oxytocin intranasal single-dose and long-term administration for individu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080861/ https://www.ncbi.nlm.nih.gov/pubmed/27071789 http://dx.doi.org/10.2174/1871527315666160413120845 |
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author | Okamoto, Yuko Ishitobi, Makoto Wada, Yuji Kosaka, Hirotaka |
author_facet | Okamoto, Yuko Ishitobi, Makoto Wada, Yuji Kosaka, Hirotaka |
author_sort | Okamoto, Yuko |
collection | PubMed |
description | Administration of oxytocin has been proposed as a treatment for the core symptoms of autism spectrum disorder (ASD), including social-communicative deficit. Previous clinical trials have investigated the efficacy and safety of oxytocin intranasal single-dose and long-term administration for individuals with ASD. All studies suggest that single-dose and long-term administration are well tolerated, and no severe adverse events have been reported. However, the efficacy of long-term oxytocin administration is controversial. Some studies have reported significant improvement of the core symptoms of ASD by long-term oxytocin administration, while other studies showed no such improvement. To elucidate the factors influencing the efficacy of oxytocin administration, it is necessary to examine the effects of administration schedules (e.g., dosage amount, frequency per day) and participant characteristics (e.g., age, sex, intellectual ability). In addition to doubts about the efficacy of particular methods of administration, questions remain about the mechanism of action of intranasal oxytocin on the central nervous system. Examination of changes in the neural underpinnings of social behavior and simultaneous oxytocin levels in blood or cerebrospinal fluid could prove important in elucidating the pharmacokinetics of intranasal oxytocin administration, which could be essential for establishing optimal oxytocin treatments for individuals with ASD. |
format | Online Article Text |
id | pubmed-5080861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-50808612016-11-14 The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders Okamoto, Yuko Ishitobi, Makoto Wada, Yuji Kosaka, Hirotaka CNS Neurol Disord Drug Targets Article Administration of oxytocin has been proposed as a treatment for the core symptoms of autism spectrum disorder (ASD), including social-communicative deficit. Previous clinical trials have investigated the efficacy and safety of oxytocin intranasal single-dose and long-term administration for individuals with ASD. All studies suggest that single-dose and long-term administration are well tolerated, and no severe adverse events have been reported. However, the efficacy of long-term oxytocin administration is controversial. Some studies have reported significant improvement of the core symptoms of ASD by long-term oxytocin administration, while other studies showed no such improvement. To elucidate the factors influencing the efficacy of oxytocin administration, it is necessary to examine the effects of administration schedules (e.g., dosage amount, frequency per day) and participant characteristics (e.g., age, sex, intellectual ability). In addition to doubts about the efficacy of particular methods of administration, questions remain about the mechanism of action of intranasal oxytocin on the central nervous system. Examination of changes in the neural underpinnings of social behavior and simultaneous oxytocin levels in blood or cerebrospinal fluid could prove important in elucidating the pharmacokinetics of intranasal oxytocin administration, which could be essential for establishing optimal oxytocin treatments for individuals with ASD. Bentham Science Publishers 2016-06 2016-06 /pmc/articles/PMC5080861/ /pubmed/27071789 http://dx.doi.org/10.2174/1871527315666160413120845 Text en © 2016 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/legalcode ), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Okamoto, Yuko Ishitobi, Makoto Wada, Yuji Kosaka, Hirotaka The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders |
title | The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders |
title_full | The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders |
title_fullStr | The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders |
title_full_unstemmed | The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders |
title_short | The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders |
title_sort | potential of nasal oxytocin administration for remediation of autism spectrum disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080861/ https://www.ncbi.nlm.nih.gov/pubmed/27071789 http://dx.doi.org/10.2174/1871527315666160413120845 |
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