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The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

Administration of oxytocin has been proposed as a treatment for the core symptoms of autism spectrum disorder (ASD), including social-communicative deficit. Previous clinical trials have investigated the efficacy and safety of oxytocin intranasal single-dose and long-term administration for individu...

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Autores principales: Okamoto, Yuko, Ishitobi, Makoto, Wada, Yuji, Kosaka, Hirotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080861/
https://www.ncbi.nlm.nih.gov/pubmed/27071789
http://dx.doi.org/10.2174/1871527315666160413120845
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author Okamoto, Yuko
Ishitobi, Makoto
Wada, Yuji
Kosaka, Hirotaka
author_facet Okamoto, Yuko
Ishitobi, Makoto
Wada, Yuji
Kosaka, Hirotaka
author_sort Okamoto, Yuko
collection PubMed
description Administration of oxytocin has been proposed as a treatment for the core symptoms of autism spectrum disorder (ASD), including social-communicative deficit. Previous clinical trials have investigated the efficacy and safety of oxytocin intranasal single-dose and long-term administration for individuals with ASD. All studies suggest that single-dose and long-term administration are well tolerated, and no severe adverse events have been reported. However, the efficacy of long-term oxytocin administration is controversial. Some studies have reported significant improvement of the core symptoms of ASD by long-term oxytocin administration, while other studies showed no such improvement. To elucidate the factors influencing the efficacy of oxytocin administration, it is necessary to examine the effects of administration schedules (e.g., dosage amount, frequency per day) and participant characteristics (e.g., age, sex, intellectual ability). In addition to doubts about the efficacy of particular methods of administration, questions remain about the mechanism of action of intranasal oxytocin on the central nervous system. Examination of changes in the neural underpinnings of social behavior and simultaneous oxytocin levels in blood or cerebrospinal fluid could prove important in elucidating the pharmacokinetics of intranasal oxytocin administration, which could be essential for establishing optimal oxytocin treatments for individuals with ASD.
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spelling pubmed-50808612016-11-14 The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders Okamoto, Yuko Ishitobi, Makoto Wada, Yuji Kosaka, Hirotaka CNS Neurol Disord Drug Targets Article Administration of oxytocin has been proposed as a treatment for the core symptoms of autism spectrum disorder (ASD), including social-communicative deficit. Previous clinical trials have investigated the efficacy and safety of oxytocin intranasal single-dose and long-term administration for individuals with ASD. All studies suggest that single-dose and long-term administration are well tolerated, and no severe adverse events have been reported. However, the efficacy of long-term oxytocin administration is controversial. Some studies have reported significant improvement of the core symptoms of ASD by long-term oxytocin administration, while other studies showed no such improvement. To elucidate the factors influencing the efficacy of oxytocin administration, it is necessary to examine the effects of administration schedules (e.g., dosage amount, frequency per day) and participant characteristics (e.g., age, sex, intellectual ability). In addition to doubts about the efficacy of particular methods of administration, questions remain about the mechanism of action of intranasal oxytocin on the central nervous system. Examination of changes in the neural underpinnings of social behavior and simultaneous oxytocin levels in blood or cerebrospinal fluid could prove important in elucidating the pharmacokinetics of intranasal oxytocin administration, which could be essential for establishing optimal oxytocin treatments for individuals with ASD. Bentham Science Publishers 2016-06 2016-06 /pmc/articles/PMC5080861/ /pubmed/27071789 http://dx.doi.org/10.2174/1871527315666160413120845 Text en © 2016 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/legalcode ), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Okamoto, Yuko
Ishitobi, Makoto
Wada, Yuji
Kosaka, Hirotaka
The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders
title The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders
title_full The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders
title_fullStr The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders
title_full_unstemmed The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders
title_short The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders
title_sort potential of nasal oxytocin administration for remediation of autism spectrum disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080861/
https://www.ncbi.nlm.nih.gov/pubmed/27071789
http://dx.doi.org/10.2174/1871527315666160413120845
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