Cargando…

PI3K/Akt/mTOR signaling & its regulator tumour suppressor genes PTEN & LKB1 in human uterine leiomyomas

BACKGROUND & OBJECTIVES: Despite their high occurrence and associated significant level of morbidity manifesting as spectrum of clinical symptoms, the pathogenesis of uterine leiomyomas (ULs) remains unclear. We investigated expression profile of tumour suppressor genes PTEN (phosphatase and ten...

Descripción completa

Detalles Bibliográficos
Autores principales:	Makker, Annu, Goel, Madhu Mati, Mahdi, Abbas Ali, Bhatia, Vikram, Das, Vinita, Agarwal, Anjoo, Pandey, Amita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080920/ https://www.ncbi.nlm.nih.gov/pubmed/27748285 http://dx.doi.org/10.4103/0971-5916.191808

Ejemplares similares

Fibroblast Growth Factor (FGF-2) and Its Receptors FGFR-2 and FGFR-3 May Be Putative Biomarkers of Malignant Transformation of Potentially Malignant Oral Lesions into Oral Squamous Cell Carcinoma
por: Nayak, Seema, et al.
Publicado: (2015)

Promoter Region Hypermethylation and mRNA Expression of MGMT and p16 Genes in Tissue and Blood Samples of Human Premalignant Oral Lesions and Oral Squamous Cell Carcinoma
por: Bhatia, Vikram, et al.
Publicado: (2014)

Lkb1 and Pten Synergise to Suppress mTOR-Mediated Tumorigenesis and Epithelial-Mesenchymal Transition in the Mouse Bladder
por: Shorning, Boris Y., et al.
Publicado: (2011)

Dysregulation of mTOR activity through LKB1 inactivation
por: Zhou, Wei, et al.
Publicado: (2013)

Elucidating the role of Lkb1 and mTOR in adipose tissue
por: Xu, Ziye, et al.
Publicado: (2018)

Phosphatase and Tensin Homolog Immunohistochemical Expression and Promoter Methylation Status in Endometrioid Endometrial Carcinoma and Its Precursor Lesions
por: Yadav, Sunita, et al.
Publicado: (2022)

Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice
por: García-Martínez, J M, et al.
Publicado: (2011)

CD3+, CD4+ & CD8+ tumour infiltrating lymphocytes (TILs) are predictors of favourable survival outcome in infiltrating ductal carcinoma of breast
por: Rathore, Ankita Singh, et al.
Publicado: (2014)

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
por: Villar, Victor H., et al.
Publicado: (2017)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

LKB1-AMPK-mTOR信号传导通路在肿瘤中的研究进展
Publicado: (2011)

LKB1 tumor suppressor: Therapeutic opportunities knock when LKB1 is inactivated
por: Zhou, Wei, et al.
Publicado: (2014)

Bladder leiomyoma presenting as uterine pedunculated leiomyoma
por: Nazari, Zeinab, et al.
Publicado: (2022)

Uterine leiomyoma with tubules
por: Pusiol, Teresa, et al.
Publicado: (2008)

Uterine Leiomyomas: An ENIGMA
por: Geethamala, Kempula, et al.
Publicado: (2016)

Ultrasonography of uterine leiomyomas
por: Woźniak, Andrzej, et al.
Publicado: (2017)

Genome-Wide DNA Methylation Indicates Silencing of Tumor Suppressor Genes in Uterine Leiomyoma
por: Navarro, Antonia, et al.
Publicado: (2012)

Pulmonary benign metastasizing leiomyoma from uterine leiomyoma
por: Chen, Sufeng, et al.
Publicado: (2013)

Primary Ovarian Leiomyoma Associated with Multiple Uterine Leiomyomas
por: Kitamura, Yoshihiro, et al.
Publicado: (2021)

Asymptomatic bacteriuria & obstetric outcome following treatment in early versus late pregnancy in north Indian women
por: Jain, Vaishali, et al.
Publicado: (2013)

The Tumor Suppressor Kinase LKB1: Metabolic Nexus
por: Bourouh, Mohammed, et al.
Publicado: (2022)

Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma
por: Lu, Jianjun, et al.
Publicado: (2015)

Multiple cutaneous and uterine leiomyomas
por: Asilian, Ali, et al.
Publicado: (2013)

Malignant transformation of uterine leiomyoma
por: Al Ansari, Afaf A., et al.
Publicado: (2013)

Immunocytochemistry versus nucleic acid amplification in fine needle aspirates and tissues of extrapulmonary tuberculosis
por: Goel, Madhu Mati, et al.
Publicado: (2012)

Role of PTEN, PI3K, and mTOR in Triple-Negative Breast Cancer
por: Prvanović, Mirjana, et al.
Publicado: (2021)

Targeting mTOR Pathway in PTEN Deleted Newly Isolated Chordoma Cell Line
por: Pagani, Francesca, et al.
Publicado: (2023)

Zosteriform pilar leiomyoma associated with uterine leiomyoma: A case report
por: Shrestha, Elisha, et al.
Publicado: (2023)

Fetomaternal outcomes in pregnant women with hepatitis E infection; still an important fetomaternal killer with an unresolved mystery of increased virulence in pregnancy
por: Kumar, Namrata, et al.
Publicado: (2017)

Pregnancy in women with previous two healthy children, associated factors, and acceptability of contraception among these women: A questionnaire-based, cross-sectional KAP study in world's second most populated country advocating two-child norm
por: Kumar, Namrata, et al.
Publicado: (2020)

Innovative Oral Treatments of Uterine Leiomyoma
por: Sabry, Mohamed, et al.
Publicado: (2012)

Hypercalcemia: An Unusual Manifestation of Uterine Leiomyoma
por: Garcha, Amarinder Singh, et al.
Publicado: (2013)

Global metabolomic profiling of uterine leiomyomas
por: Heinonen, Hanna-Riikka, et al.
Publicado: (2017)

Giant Uterine Leiomyoma With Surgical Difficulty
por: Mongan, Suzanna, et al.
Publicado: (2021)

The mTOR pathway genes mTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
por: Nguyen, Lena H., et al.
Publicado: (2023)

Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1–AMPK–mTOR axis
por: Jung, Taek-Yeol, et al.
Publicado: (2020)

Genetic variants in LKB1/AMPK/mTOR pathway are associated with clinical outcomes of chemotherapy in non‐small cell lung cancer
por: Choi, Sun Ha, et al.
Publicado: (2022)

Effect of Vitamin D3 Supplementation on Symptomatic Uterine Leiomyoma in Women with Hypovitaminosis D
por: Suneja, Amita, et al.
Publicado: (2021)

Effect of mTOR Inhibitors in Nude Mice with Endometrial Carcinoma and Variable PTEN Expression Status
por: Fong, Pedro, et al.
Publicado: (2014)

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
por: Jung, Seung Hee, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dth0la7c0j3gu999ifujfnlq84