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Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis

PURPOSE: Oxidative stress, partly due to light, has an important role in many retinal diseases, including macular degeneration and retinal dystrophies. The Leu450Met variant of RPE65 is expressed in C57BL/6 and in many genetically modified mice. It confers significant resistance to light induced ret...

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Detalles Bibliográficos
Autores principales:	Zhong, Xin, Aredo, Bogale, Ding, Yi, Zhang, Kaiyan, Zhao, Cynthia X., Ufret-Vincenty, Rafael L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2016
Materias:	Retina
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080935/ https://www.ncbi.nlm.nih.gov/pubmed/27768794 http://dx.doi.org/10.1167/iovs.16-19965

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