A deimmunised form of the ribotoxin, α-sarcin, lacking CD4(+) T cell epitopes and its use as an immunotoxin warhead

Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. α-Sarcin is a small (17 kDa) fungal ribonuclease produced by Aspergillus giganteus that functions by catalytically cleaving a single phosphodiester bond in the sarcin–ricin loop of the lar...

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Detalles Bibliográficos
Autores principales: Jones, Tim D., Hearn, Arron R., Holgate, Robert G.E., Kozub, Dorota, Fogg, Mark H., Carr, Francis J., Baker, Matthew P., Lacadena, Javier, Gehlsen, Kurt R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081043/
https://www.ncbi.nlm.nih.gov/pubmed/27578884
http://dx.doi.org/10.1093/protein/gzw045

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