Circumventing the stability-function trade-off in an engineered FN3 domain

The favorable biophysical attributes of non-antibody scaffolds make them attractive alternatives to monoclonal antibodies. However, due to the well-known stability-function trade-off, these gains tend to be marginal after functional selection. A notable example is the fibronectin Type III (FN3) doma...

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Detalles Bibliográficos
Autores principales: Porebski, Benjamin T., Conroy, Paul J., Drinkwater, Nyssa, Schofield, Peter, Vazquez-Lombardi, Rodrigo, Hunter, Morag R., Hoke, David E., Christ, Daniel, McGowan, Sheena, Buckle, Ashley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081044/
https://www.ncbi.nlm.nih.gov/pubmed/27578887
http://dx.doi.org/10.1093/protein/gzw046

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