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Very low-depth sequencing in a founder population identifies a cardioprotective APOC3 signal missed by genome-wide imputation
Cohort-wide very low-depth whole-genome sequencing (WGS) can comprehensively capture low-frequency sequence variation for the cost of a dense genome-wide genotyping array. Here, we analyse 1x sequence data across the APOC3 gene in a founder population from the island of Crete in Greece (n = 1239) an...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081052/ https://www.ncbi.nlm.nih.gov/pubmed/27146844 http://dx.doi.org/10.1093/hmg/ddw088 |