The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke

Research on commensal microbiota and its contribution to health and disease is a new and very dynamically developing field of biology and medicine. Recent experimental and clinical investigations underscore the importance of gut microbiota in the pathogenesis and course of stroke. Importantly, micro...

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Detalles Bibliográficos
Autores principales: Winek, Katarzyna, Dirnagl, Ulrich, Meisel, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081128/
https://www.ncbi.nlm.nih.gov/pubmed/27714645
http://dx.doi.org/10.1007/s13311-016-0475-x
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author Winek, Katarzyna
Dirnagl, Ulrich
Meisel, Andreas
author_facet Winek, Katarzyna
Dirnagl, Ulrich
Meisel, Andreas
author_sort Winek, Katarzyna
collection PubMed
description Research on commensal microbiota and its contribution to health and disease is a new and very dynamically developing field of biology and medicine. Recent experimental and clinical investigations underscore the importance of gut microbiota in the pathogenesis and course of stroke. Importantly, microbiota may influence the outcome of cerebral ischemia by modulating central nervous system antigen-specific immune responses. In this review we summarize studies linking gut microbiota with physiological function and disorders of the central nervous system. Based on these insights we speculate about targeting the gut microbiome in order to treat stroke. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13311-016-0475-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-50811282016-11-07 The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke Winek, Katarzyna Dirnagl, Ulrich Meisel, Andreas Neurotherapeutics Review Research on commensal microbiota and its contribution to health and disease is a new and very dynamically developing field of biology and medicine. Recent experimental and clinical investigations underscore the importance of gut microbiota in the pathogenesis and course of stroke. Importantly, microbiota may influence the outcome of cerebral ischemia by modulating central nervous system antigen-specific immune responses. In this review we summarize studies linking gut microbiota with physiological function and disorders of the central nervous system. Based on these insights we speculate about targeting the gut microbiome in order to treat stroke. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13311-016-0475-x) contains supplementary material, which is available to authorized users. Springer US 2016-10-06 2016-10 /pmc/articles/PMC5081128/ /pubmed/27714645 http://dx.doi.org/10.1007/s13311-016-0475-x Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Winek, Katarzyna
Dirnagl, Ulrich
Meisel, Andreas
The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
title The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
title_full The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
title_fullStr The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
title_full_unstemmed The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
title_short The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
title_sort gut microbiome as therapeutic target in central nervous system diseases: implications for stroke
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081128/
https://www.ncbi.nlm.nih.gov/pubmed/27714645
http://dx.doi.org/10.1007/s13311-016-0475-x
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