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Bumetanide, an Inhibitor of NKCC1 (Na-K-2Cl Cotransporter Isoform 1), Enhances Propofol-Induced Loss of Righting Reflex but Not Its Immobilizing Actions in Neonatal Rats

Gamma-aminobutyric acid (GABA) has been shown to induce excitation on immature neurons due to increased expression of Na+-K+-2Cl- co-transporter isoform 1 (NKCC1), and the transition of GABAergic signaling from excitatory to inhibitory occurs before birth in the rat spinal cord and spreads rostrally...

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Detalles Bibliográficos
Autores principales:	Koyama, Yukihide, Andoh, Tomio, Kamiya, Yoshinori, Miyazaki, Tomoyuki, Maruyama, Koichi, Kariya, Takayuki, Goto, Takahisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081196/ https://www.ncbi.nlm.nih.gov/pubmed/27783647 http://dx.doi.org/10.1371/journal.pone.0164125

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