Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis

In most Gram-negative pathogens, the hydrolysis of UDP-2,3-diacylglucosamine to generate lipid X in lipid A biosynthesis is catalyzed by the membrane-associated enzyme LpxH. We report the crystal structure of LpxH in complex with its product, lipid X, unveiling a unique insertion lid above the conse...

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Detalles Bibliográficos
Autores principales: Cho, Jae, Lee, Chul-Jin, Zhao, Jinshi, Young, Hayley E., Zhou, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081216/
https://www.ncbi.nlm.nih.gov/pubmed/27780190
http://dx.doi.org/10.1038/nmicrobiol.2016.154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081216/
https://www.ncbi.nlm.nih.gov/pubmed/27780190
http://dx.doi.org/10.1038/nmicrobiol.2016.154

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