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Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis

In most Gram-negative pathogens, the hydrolysis of UDP-2,3-diacylglucosamine to generate lipid X in lipid A biosynthesis is catalyzed by the membrane-associated enzyme LpxH. We report the crystal structure of LpxH in complex with its product, lipid X, unveiling a unique insertion lid above the conse...

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Detalles Bibliográficos
Autores principales:	Cho, Jae, Lee, Chul-Jin, Zhao, Jinshi, Young, Hayley E., Zhou, Pei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081216/ https://www.ncbi.nlm.nih.gov/pubmed/27780190 http://dx.doi.org/10.1038/nmicrobiol.2016.154

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