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Cluster Analysis of p53 Binding Site Sequences Reveals Subsets with Different Functions

p53 is an important regulator of cell cycle arrest, senescence, apoptosis and metabolism, and is frequently mutated in tumors. It functions as a tetramer, where each component dimer binds to a decameric DNA region known as a response element. We identify p53 binding site subtypes and examine the fun...

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Detalles Bibliográficos
Autores principales:	Lim, Ji-Hyun, Latysheva, Natasha S., Iggo, Richard D., Barker, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Libertas Academica 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081245/ https://www.ncbi.nlm.nih.gov/pubmed/27812278 http://dx.doi.org/10.4137/CIN.S39968

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