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Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs
Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells. The life-long accumulation of these histones has been described, yet the implications on organismal aging remain elusive. Here...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081402/ https://www.ncbi.nlm.nih.gov/pubmed/27760329 http://dx.doi.org/10.1016/j.celrep.2016.09.074 |
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author | Piazzesi, Antonia Papić, Dražen Bertan, Fabio Salomoni, Paolo Nicotera, Pierluigi Bano, Daniele |
author_facet | Piazzesi, Antonia Papić, Dražen Bertan, Fabio Salomoni, Paolo Nicotera, Pierluigi Bano, Daniele |
author_sort | Piazzesi, Antonia |
collection | PubMed |
description | Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells. The life-long accumulation of these histones has been described, yet the implications on organismal aging remain elusive. Here, we study the importance of the histone variant H3.3 in Caenorhabditis elegans longevity pathways. We show that H3.3-deficient nematodes have negligible lifespan differences compared to wild-type animals. However, H3.3 is essential for the lifespan extension of C. elegans mutants in which pronounced transcriptional changes control longevity programs. Notably, H3.3 loss critically affects the expression of a very large number of genes in long-lived nematodes, resulting in transcriptional profiles similar to wild-type animals. We conclude that H3.3 positively contributes to diverse lifespan-extending signaling pathways, with potential implications on age-related processes in multicellular organisms. |
format | Online Article Text |
id | pubmed-5081402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-50814022016-10-28 Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs Piazzesi, Antonia Papić, Dražen Bertan, Fabio Salomoni, Paolo Nicotera, Pierluigi Bano, Daniele Cell Rep Report Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells. The life-long accumulation of these histones has been described, yet the implications on organismal aging remain elusive. Here, we study the importance of the histone variant H3.3 in Caenorhabditis elegans longevity pathways. We show that H3.3-deficient nematodes have negligible lifespan differences compared to wild-type animals. However, H3.3 is essential for the lifespan extension of C. elegans mutants in which pronounced transcriptional changes control longevity programs. Notably, H3.3 loss critically affects the expression of a very large number of genes in long-lived nematodes, resulting in transcriptional profiles similar to wild-type animals. We conclude that H3.3 positively contributes to diverse lifespan-extending signaling pathways, with potential implications on age-related processes in multicellular organisms. Cell Press 2016-10-18 /pmc/articles/PMC5081402/ /pubmed/27760329 http://dx.doi.org/10.1016/j.celrep.2016.09.074 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Report Piazzesi, Antonia Papić, Dražen Bertan, Fabio Salomoni, Paolo Nicotera, Pierluigi Bano, Daniele Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs |
title | Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs |
title_full | Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs |
title_fullStr | Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs |
title_full_unstemmed | Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs |
title_short | Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs |
title_sort | replication-independent histone variant h3.3 controls animal lifespan through the regulation of pro-longevity transcriptional programs |
topic | Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081402/ https://www.ncbi.nlm.nih.gov/pubmed/27760329 http://dx.doi.org/10.1016/j.celrep.2016.09.074 |
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