Cargando…

Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs

Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells. The life-long accumulation of these histones has been described, yet the implications on organismal aging remain elusive. Here...

Descripción completa

Detalles Bibliográficos
Autores principales: Piazzesi, Antonia, Papić, Dražen, Bertan, Fabio, Salomoni, Paolo, Nicotera, Pierluigi, Bano, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081402/
https://www.ncbi.nlm.nih.gov/pubmed/27760329
http://dx.doi.org/10.1016/j.celrep.2016.09.074
_version_ 1782462884446470144
author Piazzesi, Antonia
Papić, Dražen
Bertan, Fabio
Salomoni, Paolo
Nicotera, Pierluigi
Bano, Daniele
author_facet Piazzesi, Antonia
Papić, Dražen
Bertan, Fabio
Salomoni, Paolo
Nicotera, Pierluigi
Bano, Daniele
author_sort Piazzesi, Antonia
collection PubMed
description Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells. The life-long accumulation of these histones has been described, yet the implications on organismal aging remain elusive. Here, we study the importance of the histone variant H3.3 in Caenorhabditis elegans longevity pathways. We show that H3.3-deficient nematodes have negligible lifespan differences compared to wild-type animals. However, H3.3 is essential for the lifespan extension of C. elegans mutants in which pronounced transcriptional changes control longevity programs. Notably, H3.3 loss critically affects the expression of a very large number of genes in long-lived nematodes, resulting in transcriptional profiles similar to wild-type animals. We conclude that H3.3 positively contributes to diverse lifespan-extending signaling pathways, with potential implications on age-related processes in multicellular organisms.
format Online
Article
Text
id pubmed-5081402
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Cell Press
record_format MEDLINE/PubMed
spelling pubmed-50814022016-10-28 Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs Piazzesi, Antonia Papić, Dražen Bertan, Fabio Salomoni, Paolo Nicotera, Pierluigi Bano, Daniele Cell Rep Report Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells. The life-long accumulation of these histones has been described, yet the implications on organismal aging remain elusive. Here, we study the importance of the histone variant H3.3 in Caenorhabditis elegans longevity pathways. We show that H3.3-deficient nematodes have negligible lifespan differences compared to wild-type animals. However, H3.3 is essential for the lifespan extension of C. elegans mutants in which pronounced transcriptional changes control longevity programs. Notably, H3.3 loss critically affects the expression of a very large number of genes in long-lived nematodes, resulting in transcriptional profiles similar to wild-type animals. We conclude that H3.3 positively contributes to diverse lifespan-extending signaling pathways, with potential implications on age-related processes in multicellular organisms. Cell Press 2016-10-18 /pmc/articles/PMC5081402/ /pubmed/27760329 http://dx.doi.org/10.1016/j.celrep.2016.09.074 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Report
Piazzesi, Antonia
Papić, Dražen
Bertan, Fabio
Salomoni, Paolo
Nicotera, Pierluigi
Bano, Daniele
Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs
title Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs
title_full Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs
title_fullStr Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs
title_full_unstemmed Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs
title_short Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs
title_sort replication-independent histone variant h3.3 controls animal lifespan through the regulation of pro-longevity transcriptional programs
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081402/
https://www.ncbi.nlm.nih.gov/pubmed/27760329
http://dx.doi.org/10.1016/j.celrep.2016.09.074
work_keys_str_mv AT piazzesiantonia replicationindependenthistonevarianth33controlsanimallifespanthroughtheregulationofprolongevitytranscriptionalprograms
AT papicdrazen replicationindependenthistonevarianth33controlsanimallifespanthroughtheregulationofprolongevitytranscriptionalprograms
AT bertanfabio replicationindependenthistonevarianth33controlsanimallifespanthroughtheregulationofprolongevitytranscriptionalprograms
AT salomonipaolo replicationindependenthistonevarianth33controlsanimallifespanthroughtheregulationofprolongevitytranscriptionalprograms
AT nicoterapierluigi replicationindependenthistonevarianth33controlsanimallifespanthroughtheregulationofprolongevitytranscriptionalprograms
AT banodaniele replicationindependenthistonevarianth33controlsanimallifespanthroughtheregulationofprolongevitytranscriptionalprograms