Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice

OBJECTIVE: Non-alcoholic fatty liver disease is a world-wide health concern and risk factor for cardio-metabolic diseases. Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotransporter solute carrier family 13 member 5 (SLC13A5,...

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Detalles Bibliográficos
Autores principales: Brachs, Sebastian, Winkel, Angelika F., Tang, Hui, Birkenfeld, Andreas L., Brunner, Bodo, Jahn-Hofmann, Kerstin, Margerie, Daniel, Ruetten, Hartmut, Schmoll, Dieter, Spranger, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081411/
https://www.ncbi.nlm.nih.gov/pubmed/27818933
http://dx.doi.org/10.1016/j.molmet.2016.08.004

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