Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis

To establish pathogenicity, bacteria must evade phagocytosis directed by remodeling of the actin cytoskeleton. We show that macrophages facilitate pathogen phagocytosis through actin polymerization mediated by the WAVE regulatory complex (WRC), small GTPases Arf and Rac1, and the Arf1 activator ARNO...

Descripción completa

Detalles Bibliográficos
Autores principales: Humphreys, Daniel, Singh, Vikash, Koronakis, Vassilis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081413/
https://www.ncbi.nlm.nih.gov/pubmed/27732847
http://dx.doi.org/10.1016/j.celrep.2016.09.039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081413/
https://www.ncbi.nlm.nih.gov/pubmed/27732847
http://dx.doi.org/10.1016/j.celrep.2016.09.039

Ejemplares similares