Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lep(ob/ob) mice

OBJECTIVE: Hyperinsulinemia is commonly associated with obesity. Mice deficient in the adipose-derived hormone leptin (Lep(ob/ob)) develop hyperinsulinemia prior to onset of obesity and glucose intolerance. Whether the excess of circulating insulin is a major contributor to obesity and impaired gluc...

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Detalles Bibliográficos
Autores principales: D'souza, Anna M., Johnson, James D., Clee, Susanne M., Kieffer, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081422/
https://www.ncbi.nlm.nih.gov/pubmed/27818936
http://dx.doi.org/10.1016/j.molmet.2016.09.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081422/
https://www.ncbi.nlm.nih.gov/pubmed/27818936
http://dx.doi.org/10.1016/j.molmet.2016.09.007

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