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Optogenetic Glia Manipulation: Possibilities and Future Prospects
Our brains are composed of two distinct cell types: neurons and glia. Emerging data from recent investigations show that glial cells, especially astrocytes and microglia, are able to regulate synaptic transmission and thus brain information processing. This suggests that, not only neuronal activity,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society for Brain and Neural Science
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081466/ https://www.ncbi.nlm.nih.gov/pubmed/27790054 http://dx.doi.org/10.5607/en.2016.25.5.197 |
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author | Cho, Woo-Hyun Barcelon, Ellane Lee, Sung Joong |
author_facet | Cho, Woo-Hyun Barcelon, Ellane Lee, Sung Joong |
author_sort | Cho, Woo-Hyun |
collection | PubMed |
description | Our brains are composed of two distinct cell types: neurons and glia. Emerging data from recent investigations show that glial cells, especially astrocytes and microglia, are able to regulate synaptic transmission and thus brain information processing. This suggests that, not only neuronal activity, but communication between neurons and glia also plays a key role in brain function. Thus, it is currently well known that the physiology and pathophysiology of brain function can only be completely understood by considering the interplay between neurons and glia. However, it has not yet been possible to dissect glial cell type-specific roles in higher brain functions in vivo. Meanwhile, the recent development of optogenetics techniques has allowed investigators to manipulate neural activity with unprecedented temporal and spatial precision. Recently, a series of studies suggested the possibility of applying this cutting-edge technique to manipulate glial cell activity. This review briefly discusses the feasibility of optogenetic glia manipulation, which may provide a technical innovation in elucidating the in vivo role of glial cells in complex higher brain functions. |
format | Online Article Text |
id | pubmed-5081466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Society for Brain and Neural Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50814662016-10-27 Optogenetic Glia Manipulation: Possibilities and Future Prospects Cho, Woo-Hyun Barcelon, Ellane Lee, Sung Joong Exp Neurobiol Review Article Our brains are composed of two distinct cell types: neurons and glia. Emerging data from recent investigations show that glial cells, especially astrocytes and microglia, are able to regulate synaptic transmission and thus brain information processing. This suggests that, not only neuronal activity, but communication between neurons and glia also plays a key role in brain function. Thus, it is currently well known that the physiology and pathophysiology of brain function can only be completely understood by considering the interplay between neurons and glia. However, it has not yet been possible to dissect glial cell type-specific roles in higher brain functions in vivo. Meanwhile, the recent development of optogenetics techniques has allowed investigators to manipulate neural activity with unprecedented temporal and spatial precision. Recently, a series of studies suggested the possibility of applying this cutting-edge technique to manipulate glial cell activity. This review briefly discusses the feasibility of optogenetic glia manipulation, which may provide a technical innovation in elucidating the in vivo role of glial cells in complex higher brain functions. The Korean Society for Brain and Neural Science 2016-10 2016-10-26 /pmc/articles/PMC5081466/ /pubmed/27790054 http://dx.doi.org/10.5607/en.2016.25.5.197 Text en Copyright © Experimental Neurobiology 2016. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Cho, Woo-Hyun Barcelon, Ellane Lee, Sung Joong Optogenetic Glia Manipulation: Possibilities and Future Prospects |
title | Optogenetic Glia Manipulation: Possibilities and Future Prospects |
title_full | Optogenetic Glia Manipulation: Possibilities and Future Prospects |
title_fullStr | Optogenetic Glia Manipulation: Possibilities and Future Prospects |
title_full_unstemmed | Optogenetic Glia Manipulation: Possibilities and Future Prospects |
title_short | Optogenetic Glia Manipulation: Possibilities and Future Prospects |
title_sort | optogenetic glia manipulation: possibilities and future prospects |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081466/ https://www.ncbi.nlm.nih.gov/pubmed/27790054 http://dx.doi.org/10.5607/en.2016.25.5.197 |
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