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Crystal structures and inhibition of Trypanosoma brucei hypoxanthine–guanine phosphoribosyltransferase

Human African Trypanosomiasis (HAT) is a life-threatening infectious disease caused by the protozoan parasite, Trypanosoma brucei (Tbr). Due to the debilitating side effects of the current therapeutics and the emergence of resistance to these drugs, new medications for this disease need to be develo...

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Detalles Bibliográficos
Autores principales:	Terán, David, Hocková, Dana, Česnek, Michal, Zíková, Alena, Naesens, Lieve, Keough, Dianne T., Guddat, Luke W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081515/ https://www.ncbi.nlm.nih.gov/pubmed/27786284 http://dx.doi.org/10.1038/srep35894

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