Cristae remodeling causes acidification detected by integrated graphene sensor during mitochondrial outer membrane permeabilization

The intrinsic apoptotic pathway and the resultant mitochondrial outer membrane permeabilization (MOMP) via BAK and BAX oligomerization, cytochrome c (cytc) release, and caspase activation are well studied, but their effect on cytosolic pH is poorly understood. Using isolated mitochondria, we show th...

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Detalles Bibliográficos
Autores principales: Pham, Ted D., Pham, Phi Q., Li, Jinfeng, Letai, Anthony G., Wallace, Douglas C., Burke, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081517/
https://www.ncbi.nlm.nih.gov/pubmed/27786282
http://dx.doi.org/10.1038/srep35907

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