Identification of New Structural Fragments for the Design of Lactate Dehydrogenase A Inhibitors

Human lactate dehydrogenase A plays an important role in the glucose metabolism of tumor cells and constitutes an attractive target for chemotherapy. Molecular fragments able to bind in the active site of this enzyme and form hydrogen bonds with the Arg168 guanidinium group, as well as additional in...

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Detalles Bibliográficos
Autores principales: Nilov, D.K., Kulikov, A.V., Prokhorova, E.A., Švedas, V.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081701/
https://www.ncbi.nlm.nih.gov/pubmed/27795851

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