The Effect of Dopamine Secreted by the Brain into the Systemic Circulation on Prolactin Synthesis by the Pituitary gland in Ontogenesis

This research was aimed at studying the brain’s endocrine function in ontogenesis. It has been previously shown in our laboratory that the brain serves as the source of dopamine in the systemic circulation of rats prior to the formation of the blood-brain barrier. This paper provides direct evidence...

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Autores principales: Nikishina, Yu.O., Sapronova, A.Ya., Ugrumov, M.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081709/
https://www.ncbi.nlm.nih.gov/pubmed/27795850
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author Nikishina, Yu.O.
Sapronova, A.Ya.
Ugrumov, M.V.
author_facet Nikishina, Yu.O.
Sapronova, A.Ya.
Ugrumov, M.V.
author_sort Nikishina, Yu.O.
collection PubMed
description This research was aimed at studying the brain’s endocrine function in ontogenesis. It has been previously shown in our laboratory that the brain serves as the source of dopamine in the systemic circulation of rats prior to the formation of the blood-brain barrier. This paper provides direct evidence that dopamine secreted by the brain directly into the systemic circulation in this period of ontogenesis has an inhibitory effect on prolactin secretion by pituitary cells. These results provide the basis for a fundamentally new understanding of the brain’s role in the neuroendocrine regulation of the development and function of peripheral target organs and, particularly in this study, the pituitary gland.
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spelling pubmed-50817092016-10-28 The Effect of Dopamine Secreted by the Brain into the Systemic Circulation on Prolactin Synthesis by the Pituitary gland in Ontogenesis Nikishina, Yu.O. Sapronova, A.Ya. Ugrumov, M.V. Acta Naturae Research Article This research was aimed at studying the brain’s endocrine function in ontogenesis. It has been previously shown in our laboratory that the brain serves as the source of dopamine in the systemic circulation of rats prior to the formation of the blood-brain barrier. This paper provides direct evidence that dopamine secreted by the brain directly into the systemic circulation in this period of ontogenesis has an inhibitory effect on prolactin secretion by pituitary cells. These results provide the basis for a fundamentally new understanding of the brain’s role in the neuroendocrine regulation of the development and function of peripheral target organs and, particularly in this study, the pituitary gland. A.I. Gordeyev 2016 /pmc/articles/PMC5081709/ /pubmed/27795850 Text en Copyright ® 2016 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nikishina, Yu.O.
Sapronova, A.Ya.
Ugrumov, M.V.
The Effect of Dopamine Secreted by the Brain into the Systemic Circulation on Prolactin Synthesis by the Pituitary gland in Ontogenesis
title The Effect of Dopamine Secreted by the Brain into the Systemic Circulation on Prolactin Synthesis by the Pituitary gland in Ontogenesis
title_full The Effect of Dopamine Secreted by the Brain into the Systemic Circulation on Prolactin Synthesis by the Pituitary gland in Ontogenesis
title_fullStr The Effect of Dopamine Secreted by the Brain into the Systemic Circulation on Prolactin Synthesis by the Pituitary gland in Ontogenesis
title_full_unstemmed The Effect of Dopamine Secreted by the Brain into the Systemic Circulation on Prolactin Synthesis by the Pituitary gland in Ontogenesis
title_short The Effect of Dopamine Secreted by the Brain into the Systemic Circulation on Prolactin Synthesis by the Pituitary gland in Ontogenesis
title_sort effect of dopamine secreted by the brain into the systemic circulation on prolactin synthesis by the pituitary gland in ontogenesis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081709/
https://www.ncbi.nlm.nih.gov/pubmed/27795850
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