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Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites
Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4–11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082328/ https://www.ncbi.nlm.nih.gov/pubmed/27727166 http://dx.doi.org/10.3390/md14100180 |
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author | Huang, Chiung-Yao Chang, Che-Wei Tseng, Yen-Ju Lee, Jessica Sung, Ping-Jyun Su, Jui-Hsin Hwang, Tsong-Long Dai, Chang-Feng Wang, Hui-Chun Sheu, Jyh-Horng |
author_facet | Huang, Chiung-Yao Chang, Che-Wei Tseng, Yen-Ju Lee, Jessica Sung, Ping-Jyun Su, Jui-Hsin Hwang, Tsong-Long Dai, Chang-Feng Wang, Hui-Chun Sheu, Jyh-Horng |
author_sort | Huang, Chiung-Yao |
collection | PubMed |
description | Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4–11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 1–3 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 1–11 were also examined to evaluate the anti-inflammatory potential, and 2–4 were shown to exhibit significant activities. |
format | Online Article Text |
id | pubmed-5082328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-50823282016-10-28 Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites Huang, Chiung-Yao Chang, Che-Wei Tseng, Yen-Ju Lee, Jessica Sung, Ping-Jyun Su, Jui-Hsin Hwang, Tsong-Long Dai, Chang-Feng Wang, Hui-Chun Sheu, Jyh-Horng Mar Drugs Article Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4–11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 1–3 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 1–11 were also examined to evaluate the anti-inflammatory potential, and 2–4 were shown to exhibit significant activities. MDPI 2016-10-11 /pmc/articles/PMC5082328/ /pubmed/27727166 http://dx.doi.org/10.3390/md14100180 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Chiung-Yao Chang, Che-Wei Tseng, Yen-Ju Lee, Jessica Sung, Ping-Jyun Su, Jui-Hsin Hwang, Tsong-Long Dai, Chang-Feng Wang, Hui-Chun Sheu, Jyh-Horng Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites |
title | Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites |
title_full | Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites |
title_fullStr | Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites |
title_full_unstemmed | Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites |
title_short | Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites |
title_sort | bioactive steroids from the formosan soft coral umbellulifera petasites |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082328/ https://www.ncbi.nlm.nih.gov/pubmed/27727166 http://dx.doi.org/10.3390/md14100180 |
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