Cargando…

Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites

Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4–11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Chiung-Yao, Chang, Che-Wei, Tseng, Yen-Ju, Lee, Jessica, Sung, Ping-Jyun, Su, Jui-Hsin, Hwang, Tsong-Long, Dai, Chang-Feng, Wang, Hui-Chun, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082328/
https://www.ncbi.nlm.nih.gov/pubmed/27727166
http://dx.doi.org/10.3390/md14100180
_version_ 1782463033844432896
author Huang, Chiung-Yao
Chang, Che-Wei
Tseng, Yen-Ju
Lee, Jessica
Sung, Ping-Jyun
Su, Jui-Hsin
Hwang, Tsong-Long
Dai, Chang-Feng
Wang, Hui-Chun
Sheu, Jyh-Horng
author_facet Huang, Chiung-Yao
Chang, Che-Wei
Tseng, Yen-Ju
Lee, Jessica
Sung, Ping-Jyun
Su, Jui-Hsin
Hwang, Tsong-Long
Dai, Chang-Feng
Wang, Hui-Chun
Sheu, Jyh-Horng
author_sort Huang, Chiung-Yao
collection PubMed
description Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4–11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 1–3 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 1–11 were also examined to evaluate the anti-inflammatory potential, and 2–4 were shown to exhibit significant activities.
format Online
Article
Text
id pubmed-5082328
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-50823282016-10-28 Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites Huang, Chiung-Yao Chang, Che-Wei Tseng, Yen-Ju Lee, Jessica Sung, Ping-Jyun Su, Jui-Hsin Hwang, Tsong-Long Dai, Chang-Feng Wang, Hui-Chun Sheu, Jyh-Horng Mar Drugs Article Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4–11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 1–3 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 1–11 were also examined to evaluate the anti-inflammatory potential, and 2–4 were shown to exhibit significant activities. MDPI 2016-10-11 /pmc/articles/PMC5082328/ /pubmed/27727166 http://dx.doi.org/10.3390/md14100180 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Chiung-Yao
Chang, Che-Wei
Tseng, Yen-Ju
Lee, Jessica
Sung, Ping-Jyun
Su, Jui-Hsin
Hwang, Tsong-Long
Dai, Chang-Feng
Wang, Hui-Chun
Sheu, Jyh-Horng
Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites
title Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites
title_full Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites
title_fullStr Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites
title_full_unstemmed Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites
title_short Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites
title_sort bioactive steroids from the formosan soft coral umbellulifera petasites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082328/
https://www.ncbi.nlm.nih.gov/pubmed/27727166
http://dx.doi.org/10.3390/md14100180
work_keys_str_mv AT huangchiungyao bioactivesteroidsfromtheformosansoftcoralumbelluliferapetasites
AT changchewei bioactivesteroidsfromtheformosansoftcoralumbelluliferapetasites
AT tsengyenju bioactivesteroidsfromtheformosansoftcoralumbelluliferapetasites
AT leejessica bioactivesteroidsfromtheformosansoftcoralumbelluliferapetasites
AT sungpingjyun bioactivesteroidsfromtheformosansoftcoralumbelluliferapetasites
AT sujuihsin bioactivesteroidsfromtheformosansoftcoralumbelluliferapetasites
AT hwangtsonglong bioactivesteroidsfromtheformosansoftcoralumbelluliferapetasites
AT daichangfeng bioactivesteroidsfromtheformosansoftcoralumbelluliferapetasites
AT wanghuichun bioactivesteroidsfromtheformosansoftcoralumbelluliferapetasites
AT sheujyhhorng bioactivesteroidsfromtheformosansoftcoralumbelluliferapetasites