A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66

The wblA(so) gene functions as a global regulatory gene in a negative manner in deepsea-derived Streptomyces somaliensis SCSIO ZH66. A new dioic acid (1) as well as two known butenolides (2 and 3) were isolated from the ΔwblA(so) mutant strain of S. somaliensis SCSIO ZH66. The structure of 1 was elu...

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Detalles Bibliográficos
Autores principales: Huang, Huiming, Li, Huayue, Qiu, Yanhong, Hou, Lukuan, Ju, Jianhua, Li, Wenli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082332/
https://www.ncbi.nlm.nih.gov/pubmed/27763499
http://dx.doi.org/10.3390/md14100184
Descripción
Sumario:The wblA(so) gene functions as a global regulatory gene in a negative manner in deepsea-derived Streptomyces somaliensis SCSIO ZH66. A new dioic acid (1) as well as two known butenolides (2 and 3) were isolated from the ΔwblA(so) mutant strain of S. somaliensis SCSIO ZH66. The structure of 1 was elucidated by a combination of spectroscopic analyses, including MS and NMR techniques. In the cell growth inhibitory evaluation, compound 3 exhibited moderate activity against the human hepatic carcinoma cell line (Huh7.5) with an IC(50) value of 19.4 μg/mL, while compounds 1 and 2 showed null activity up to 100 μg/mL.

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