Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster hesperus

Three new polyhydroxysteroidal glycosides, hesperuside A (1), B (2), and C (3), as well as a known novaeguinoside A (4), were isolated from the ethanol extract of starfish Craspidaster hesperus collected from the South China Sea. Their structures were elucidated by extensive spectroscopic methods an...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, Jun-Xia, Kang, Yong-Feng, Han, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082337/
https://www.ncbi.nlm.nih.gov/pubmed/27775561
http://dx.doi.org/10.3390/md14100189
_version_ 1782463036055879680
author Kang, Jun-Xia
Kang, Yong-Feng
Han, Hua
author_facet Kang, Jun-Xia
Kang, Yong-Feng
Han, Hua
author_sort Kang, Jun-Xia
collection PubMed
description Three new polyhydroxysteroidal glycosides, hesperuside A (1), B (2), and C (3), as well as a known novaeguinoside A (4), were isolated from the ethanol extract of starfish Craspidaster hesperus collected from the South China Sea. Their structures were elucidated by extensive spectroscopic methods and chemical evidence. The compounds 1–3 present unprecedented carbohydrate chain 3-O-methyl-β-d-galactopyranose, which differ from each other in the side chains. These compounds exhibited cytotoxicity against human tumor cells BEL-7402, MOLT-4, and A-549 in vitro.
format Online
Article
Text
id pubmed-5082337
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-50823372016-10-28 Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster hesperus Kang, Jun-Xia Kang, Yong-Feng Han, Hua Mar Drugs Article Three new polyhydroxysteroidal glycosides, hesperuside A (1), B (2), and C (3), as well as a known novaeguinoside A (4), were isolated from the ethanol extract of starfish Craspidaster hesperus collected from the South China Sea. Their structures were elucidated by extensive spectroscopic methods and chemical evidence. The compounds 1–3 present unprecedented carbohydrate chain 3-O-methyl-β-d-galactopyranose, which differ from each other in the side chains. These compounds exhibited cytotoxicity against human tumor cells BEL-7402, MOLT-4, and A-549 in vitro. MDPI 2016-10-19 /pmc/articles/PMC5082337/ /pubmed/27775561 http://dx.doi.org/10.3390/md14100189 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kang, Jun-Xia
Kang, Yong-Feng
Han, Hua
Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster hesperus
title Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster hesperus
title_full Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster hesperus
title_fullStr Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster hesperus
title_full_unstemmed Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster hesperus
title_short Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster hesperus
title_sort three new cytotoxic polyhydroxysteroidal glycosides from starfish craspidaster hesperus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082337/
https://www.ncbi.nlm.nih.gov/pubmed/27775561
http://dx.doi.org/10.3390/md14100189
work_keys_str_mv AT kangjunxia threenewcytotoxicpolyhydroxysteroidalglycosidesfromstarfishcraspidasterhesperus
AT kangyongfeng threenewcytotoxicpolyhydroxysteroidalglycosidesfromstarfishcraspidasterhesperus
AT hanhua threenewcytotoxicpolyhydroxysteroidalglycosidesfromstarfishcraspidasterhesperus

Ejemplares similares