Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1

The pathogenesis of Plasmodium falciparum malaria involves a complex interplay between parasite adhesion and inflammatory response that includes release of cytokines and activation of the endothelium with accompanying release of Angiopoitin 2 (Ang2) to the plasma. A-disintegrin and metalloproteinase...

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Detalles Bibliográficos
Autores principales: Petersen, Jens E. V., Mkumbaye, Sixbert I., Vaaben, Anna V., Manjurano, Alphaxard, Lyimo, Eric, Kavishe, Reginald A., Mwakalinga, Steven B., Mosha, Jacklin, Minja, Daniel T. R., Lusingu, John P. A., Theander, Thor G., Lavstsen, Thomas, Wang, Christian W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082358/
https://www.ncbi.nlm.nih.gov/pubmed/27784899
http://dx.doi.org/10.1038/srep35950

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