Skin appendage-derived stem cells: cell biology and potential for wound repair

Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration. These stem cells also participate in the repair of the epidermis after injuries, inducing restoration of tissue integrity and function of damaged tissue. Unlike epidermis-derived stem cells...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Jiangfan, Yao, Bin, Han, Yutong, Huang, Sha, Fu, Xiaobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082359/
https://www.ncbi.nlm.nih.gov/pubmed/27800498
http://dx.doi.org/10.1186/s41038-016-0064-6
_version_ 1782463041027178496
author Xie, Jiangfan
Yao, Bin
Han, Yutong
Huang, Sha
Fu, Xiaobing
author_facet Xie, Jiangfan
Yao, Bin
Han, Yutong
Huang, Sha
Fu, Xiaobing
author_sort Xie, Jiangfan
collection PubMed
description Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration. These stem cells also participate in the repair of the epidermis after injuries, inducing restoration of tissue integrity and function of damaged tissue. Unlike epidermis-derived stem cells, comprehensive knowledge about skin appendage-derived stem cells remains limited. In this review, we summarize the current knowledge of skin appendage-derived stem cells, including their fundamental characteristics, their preferentially expressed biomarkers, and their potential contribution involved in wound repair. Finally, we will also discuss current strategies, future applications, and limitations of these stem cells, attempting to provide some perspectives on optimizing the available therapy in cutaneous repair and regeneration.
format Online
Article
Text
id pubmed-5082359
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-50823592016-10-31 Skin appendage-derived stem cells: cell biology and potential for wound repair Xie, Jiangfan Yao, Bin Han, Yutong Huang, Sha Fu, Xiaobing Burns Trauma Review Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration. These stem cells also participate in the repair of the epidermis after injuries, inducing restoration of tissue integrity and function of damaged tissue. Unlike epidermis-derived stem cells, comprehensive knowledge about skin appendage-derived stem cells remains limited. In this review, we summarize the current knowledge of skin appendage-derived stem cells, including their fundamental characteristics, their preferentially expressed biomarkers, and their potential contribution involved in wound repair. Finally, we will also discuss current strategies, future applications, and limitations of these stem cells, attempting to provide some perspectives on optimizing the available therapy in cutaneous repair and regeneration. BioMed Central 2016-10-26 /pmc/articles/PMC5082359/ /pubmed/27800498 http://dx.doi.org/10.1186/s41038-016-0064-6 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Xie, Jiangfan
Yao, Bin
Han, Yutong
Huang, Sha
Fu, Xiaobing
Skin appendage-derived stem cells: cell biology and potential for wound repair
title Skin appendage-derived stem cells: cell biology and potential for wound repair
title_full Skin appendage-derived stem cells: cell biology and potential for wound repair
title_fullStr Skin appendage-derived stem cells: cell biology and potential for wound repair
title_full_unstemmed Skin appendage-derived stem cells: cell biology and potential for wound repair
title_short Skin appendage-derived stem cells: cell biology and potential for wound repair
title_sort skin appendage-derived stem cells: cell biology and potential for wound repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082359/
https://www.ncbi.nlm.nih.gov/pubmed/27800498
http://dx.doi.org/10.1186/s41038-016-0064-6
work_keys_str_mv AT xiejiangfan skinappendagederivedstemcellscellbiologyandpotentialforwoundrepair
AT yaobin skinappendagederivedstemcellscellbiologyandpotentialforwoundrepair
AT hanyutong skinappendagederivedstemcellscellbiologyandpotentialforwoundrepair
AT huangsha skinappendagederivedstemcellscellbiologyandpotentialforwoundrepair
AT fuxiaobing skinappendagederivedstemcellscellbiologyandpotentialforwoundrepair

Ejemplares similares