Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation

Pd-catalysed C–C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Here...

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Detalles Bibliográficos
Autores principales: Wilson, Kirsty L, Kennedy, Alan R, Murray, Jane, Greatrex, Ben, Jamieson, Craig, Watson, Allan J B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082449/
https://www.ncbi.nlm.nih.gov/pubmed/27829904
http://dx.doi.org/10.3762/bjoc.12.187
Descripción
Sumario:Pd-catalysed C–C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources (Cyrene(TM)) in Sonogashira cross-coupling and Cacchi-type annulations.

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