Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation

Pd-catalysed C–C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Here...

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Autores principales: Wilson, Kirsty L, Kennedy, Alan R, Murray, Jane, Greatrex, Ben, Jamieson, Craig, Watson, Allan J B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082449/
https://www.ncbi.nlm.nih.gov/pubmed/27829904
http://dx.doi.org/10.3762/bjoc.12.187
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author Wilson, Kirsty L
Kennedy, Alan R
Murray, Jane
Greatrex, Ben
Jamieson, Craig
Watson, Allan J B
author_facet Wilson, Kirsty L
Kennedy, Alan R
Murray, Jane
Greatrex, Ben
Jamieson, Craig
Watson, Allan J B
author_sort Wilson, Kirsty L
collection PubMed
description Pd-catalysed C–C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources (Cyrene(TM)) in Sonogashira cross-coupling and Cacchi-type annulations.
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spelling pubmed-50824492016-11-09 Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation Wilson, Kirsty L Kennedy, Alan R Murray, Jane Greatrex, Ben Jamieson, Craig Watson, Allan J B Beilstein J Org Chem Full Research Paper Pd-catalysed C–C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources (Cyrene(TM)) in Sonogashira cross-coupling and Cacchi-type annulations. Beilstein-Institut 2016-09-08 /pmc/articles/PMC5082449/ /pubmed/27829904 http://dx.doi.org/10.3762/bjoc.12.187 Text en Copyright © 2016, Wilson et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Wilson, Kirsty L
Kennedy, Alan R
Murray, Jane
Greatrex, Ben
Jamieson, Craig
Watson, Allan J B
Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation
title Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation
title_full Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation
title_fullStr Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation
title_full_unstemmed Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation
title_short Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation
title_sort scope and limitations of a dmf bio-alternative within sonogashira cross-coupling and cacchi-type annulation
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082449/
https://www.ncbi.nlm.nih.gov/pubmed/27829904
http://dx.doi.org/10.3762/bjoc.12.187
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