Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite

We achieved the synthesis of important medronic acid monoalkyl esters via the dealkylation of mixed trimethyl monoalkyl esters of medronic acid. Two methods were developed for the purification of medronic acid monoesters: 1) small scale (10–20 mg) purification by using hydroxyapatite and 2) large sc...

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Autores principales: Puljula, Elina, Vepsäläinen, Jouko, Turhanen, Petri A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082484/
https://www.ncbi.nlm.nih.gov/pubmed/27829921
http://dx.doi.org/10.3762/bjoc.12.204
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author Puljula, Elina
Vepsäläinen, Jouko
Turhanen, Petri A
author_facet Puljula, Elina
Vepsäläinen, Jouko
Turhanen, Petri A
author_sort Puljula, Elina
collection PubMed
description We achieved the synthesis of important medronic acid monoalkyl esters via the dealkylation of mixed trimethyl monoalkyl esters of medronic acid. Two methods were developed for the purification of medronic acid monoesters: 1) small scale (10–20 mg) purification by using hydroxyapatite and 2) large scale (tested up to 140 mg) purification by high-performance countercurrent chromatography (HPCCC).
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spelling pubmed-50824842016-11-09 Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite Puljula, Elina Vepsäläinen, Jouko Turhanen, Petri A Beilstein J Org Chem Full Research Paper We achieved the synthesis of important medronic acid monoalkyl esters via the dealkylation of mixed trimethyl monoalkyl esters of medronic acid. Two methods were developed for the purification of medronic acid monoesters: 1) small scale (10–20 mg) purification by using hydroxyapatite and 2) large scale (tested up to 140 mg) purification by high-performance countercurrent chromatography (HPCCC). Beilstein-Institut 2016-10-07 /pmc/articles/PMC5082484/ /pubmed/27829921 http://dx.doi.org/10.3762/bjoc.12.204 Text en Copyright © 2016, Puljula et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Puljula, Elina
Vepsäläinen, Jouko
Turhanen, Petri A
Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite
title Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite
title_full Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite
title_fullStr Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite
title_full_unstemmed Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite
title_short Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite
title_sort synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082484/
https://www.ncbi.nlm.nih.gov/pubmed/27829921
http://dx.doi.org/10.3762/bjoc.12.204
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