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Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite
We achieved the synthesis of important medronic acid monoalkyl esters via the dealkylation of mixed trimethyl monoalkyl esters of medronic acid. Two methods were developed for the purification of medronic acid monoesters: 1) small scale (10–20 mg) purification by using hydroxyapatite and 2) large sc...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082484/ https://www.ncbi.nlm.nih.gov/pubmed/27829921 http://dx.doi.org/10.3762/bjoc.12.204 |