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Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease‐related H109R variant

The human dimethylglycine dehydrogenase (hDMGDH) is a flavin adenine dinucleotide (FAD)‐ and tetrahydrofolate (THF)‐dependent, mitochondrial matrix enzyme taking part in choline degradation, one‐carbon metabolism and electron transfer to the respiratory chain. The rare natural variant H109R causes d...

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Detalles Bibliográficos
Autores principales:	Augustin, Peter, Hromic, Altijana, Pavkov‐Keller, Tea, Gruber, Karl, Macheroux, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082570/ https://www.ncbi.nlm.nih.gov/pubmed/27486859 http://dx.doi.org/10.1111/febs.13828

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