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Assessment of Interleukin 16 Serum Levels and Skin Expression in Psoriasis Patients in Correlation with Clinical Severity of the Disease

Interleukin 16 (IL-16) has been described as a significant cytokine involved in the recruitment of CD4+ cells during inflammation; however, its potential role in psoriasis has not been defined. Our aim was to investigate the IL-16 serum levels and IL-16 mRNA skin expression in psoriasis patients in...

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Autores principales: Purzycka-Bohdan, Dorota, Szczerkowska-Dobosz, Aneta, Zablotna, Monika, Wierzbicka, Justyna, Piotrowska, Anna, Zmijewski, Michal A., Nedoszytko, Boguslaw, Nowicki, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082815/
https://www.ncbi.nlm.nih.gov/pubmed/27788245
http://dx.doi.org/10.1371/journal.pone.0165577
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author Purzycka-Bohdan, Dorota
Szczerkowska-Dobosz, Aneta
Zablotna, Monika
Wierzbicka, Justyna
Piotrowska, Anna
Zmijewski, Michal A.
Nedoszytko, Boguslaw
Nowicki, Roman
author_facet Purzycka-Bohdan, Dorota
Szczerkowska-Dobosz, Aneta
Zablotna, Monika
Wierzbicka, Justyna
Piotrowska, Anna
Zmijewski, Michal A.
Nedoszytko, Boguslaw
Nowicki, Roman
author_sort Purzycka-Bohdan, Dorota
collection PubMed
description Interleukin 16 (IL-16) has been described as a significant cytokine involved in the recruitment of CD4+ cells during inflammation; however, its potential role in psoriasis has not been defined. Our aim was to investigate the IL-16 serum levels and IL-16 mRNA skin expression in psoriasis patients in correlation with disease severity and mRNA skin expression for CD4. Moreover, the IL-16 skin localization was assessed and the -295 T/C IL-16 polymorphism was analyzed. For this exploratory, observational, and cross-sectional study, 97 unrelated patients with chronic plaque type psoriasis and 104 healthy controls were enrolled. IL-16 serum levels were significantly increased in patients compared with controls (P = 0.000022) and positively correlated with Psoriasis Area and Severity Index (r = 0.34, P = 0.0007), Body Surface Area (r = 0.34, P = 0.01) and were significantly higher in individuals with moderate to severe psoriasis (P = 0.0029). There was no significant correlation between IL-16 serum levels and Dermatology Quality of Life Index and no differences in genotype and allele frequencies for -295 T/C IL-16 polymorphism. The expression of IL-16 (mRNA and protein) was elevated in the margin of psoriatic skin while statistically significant increase in IL-16 immunoreactivity, but not in mRNA level, was observed within plaques. Furthermore, the IL-16 mRNA levels within psoriatic lesions positively correlated with the levels of CD4 mRNA, but not with Psoriasis Area and Severity Index. In conclusion, our data revealed an association between circulating IL-16 and severity of psoriasis which indicates that this cytokine could serve as a potential marker of disease activity. However, further investigations are required.
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spelling pubmed-50828152016-11-04 Assessment of Interleukin 16 Serum Levels and Skin Expression in Psoriasis Patients in Correlation with Clinical Severity of the Disease Purzycka-Bohdan, Dorota Szczerkowska-Dobosz, Aneta Zablotna, Monika Wierzbicka, Justyna Piotrowska, Anna Zmijewski, Michal A. Nedoszytko, Boguslaw Nowicki, Roman PLoS One Research Article Interleukin 16 (IL-16) has been described as a significant cytokine involved in the recruitment of CD4+ cells during inflammation; however, its potential role in psoriasis has not been defined. Our aim was to investigate the IL-16 serum levels and IL-16 mRNA skin expression in psoriasis patients in correlation with disease severity and mRNA skin expression for CD4. Moreover, the IL-16 skin localization was assessed and the -295 T/C IL-16 polymorphism was analyzed. For this exploratory, observational, and cross-sectional study, 97 unrelated patients with chronic plaque type psoriasis and 104 healthy controls were enrolled. IL-16 serum levels were significantly increased in patients compared with controls (P = 0.000022) and positively correlated with Psoriasis Area and Severity Index (r = 0.34, P = 0.0007), Body Surface Area (r = 0.34, P = 0.01) and were significantly higher in individuals with moderate to severe psoriasis (P = 0.0029). There was no significant correlation between IL-16 serum levels and Dermatology Quality of Life Index and no differences in genotype and allele frequencies for -295 T/C IL-16 polymorphism. The expression of IL-16 (mRNA and protein) was elevated in the margin of psoriatic skin while statistically significant increase in IL-16 immunoreactivity, but not in mRNA level, was observed within plaques. Furthermore, the IL-16 mRNA levels within psoriatic lesions positively correlated with the levels of CD4 mRNA, but not with Psoriasis Area and Severity Index. In conclusion, our data revealed an association between circulating IL-16 and severity of psoriasis which indicates that this cytokine could serve as a potential marker of disease activity. However, further investigations are required. Public Library of Science 2016-10-27 /pmc/articles/PMC5082815/ /pubmed/27788245 http://dx.doi.org/10.1371/journal.pone.0165577 Text en © 2016 Purzycka-Bohdan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Purzycka-Bohdan, Dorota
Szczerkowska-Dobosz, Aneta
Zablotna, Monika
Wierzbicka, Justyna
Piotrowska, Anna
Zmijewski, Michal A.
Nedoszytko, Boguslaw
Nowicki, Roman
Assessment of Interleukin 16 Serum Levels and Skin Expression in Psoriasis Patients in Correlation with Clinical Severity of the Disease
title Assessment of Interleukin 16 Serum Levels and Skin Expression in Psoriasis Patients in Correlation with Clinical Severity of the Disease
title_full Assessment of Interleukin 16 Serum Levels and Skin Expression in Psoriasis Patients in Correlation with Clinical Severity of the Disease
title_fullStr Assessment of Interleukin 16 Serum Levels and Skin Expression in Psoriasis Patients in Correlation with Clinical Severity of the Disease
title_full_unstemmed Assessment of Interleukin 16 Serum Levels and Skin Expression in Psoriasis Patients in Correlation with Clinical Severity of the Disease
title_short Assessment of Interleukin 16 Serum Levels and Skin Expression in Psoriasis Patients in Correlation with Clinical Severity of the Disease
title_sort assessment of interleukin 16 serum levels and skin expression in psoriasis patients in correlation with clinical severity of the disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082815/
https://www.ncbi.nlm.nih.gov/pubmed/27788245
http://dx.doi.org/10.1371/journal.pone.0165577
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