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Characterization of Autoantigens Targeted by Anti-Citrullinated Protein Antibodies In Vivo: Prominent Role for Epitopes Derived from Histone 4 Proteins

Anti-citrullinated protein antibodies (ACPA) have become an integral part of the clinical definition of rheumatoid arthritis, and are hypothesized to be important in the immunopathogenesis of this autoimmune disease. Several citrullinated proteins have been demonstrated to serve as candidate autoant...

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Detalles Bibliográficos
Autores principales: Meng, Xiaobo, Ezzati, Peyman, Smolik, Irene, Bernstein, Charles N., Hitchon, Carol Ann, El-Gabalawy, Hani S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082836/
https://www.ncbi.nlm.nih.gov/pubmed/27788229
http://dx.doi.org/10.1371/journal.pone.0165501