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A Viral Immunity Chromosome in the Marine Picoeukaryote, Ostreococcus tauri
Micro-algae of the genus Ostreococcus and related species of the order Mamiellales are globally distributed in the photic zone of world's oceans where they contribute to fixation of atmospheric carbon and production of oxygen, besides providing a primary source of nutrition in the food web. The...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082852/ https://www.ncbi.nlm.nih.gov/pubmed/27788272 http://dx.doi.org/10.1371/journal.ppat.1005965 |
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author | Yau, Sheree Hemon, Claire Derelle, Evelyne Moreau, Hervé Piganeau, Gwenaël Grimsley, Nigel |
author_facet | Yau, Sheree Hemon, Claire Derelle, Evelyne Moreau, Hervé Piganeau, Gwenaël Grimsley, Nigel |
author_sort | Yau, Sheree |
collection | PubMed |
description | Micro-algae of the genus Ostreococcus and related species of the order Mamiellales are globally distributed in the photic zone of world's oceans where they contribute to fixation of atmospheric carbon and production of oxygen, besides providing a primary source of nutrition in the food web. Their tiny size, simple cells, ease of culture, compact genomes and susceptibility to the most abundant large DNA viruses in the sea render them attractive as models for integrative marine biology. In culture, spontaneous resistance to viruses occurs frequently. Here, we show that virus-producing resistant cell lines arise in many independent cell lines during lytic infections, but over two years, more and more of these lines stop producing viruses. We observed sweeping over-expression of all genes in more than half of chromosome 19 in resistant lines, and karyotypic analyses showed physical rearrangements of this chromosome. Chromosome 19 has an unusual genetic structure whose equivalent is found in all of the sequenced genomes in this ecologically important group of green algae. |
format | Online Article Text |
id | pubmed-5082852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50828522016-11-04 A Viral Immunity Chromosome in the Marine Picoeukaryote, Ostreococcus tauri Yau, Sheree Hemon, Claire Derelle, Evelyne Moreau, Hervé Piganeau, Gwenaël Grimsley, Nigel PLoS Pathog Research Article Micro-algae of the genus Ostreococcus and related species of the order Mamiellales are globally distributed in the photic zone of world's oceans where they contribute to fixation of atmospheric carbon and production of oxygen, besides providing a primary source of nutrition in the food web. Their tiny size, simple cells, ease of culture, compact genomes and susceptibility to the most abundant large DNA viruses in the sea render them attractive as models for integrative marine biology. In culture, spontaneous resistance to viruses occurs frequently. Here, we show that virus-producing resistant cell lines arise in many independent cell lines during lytic infections, but over two years, more and more of these lines stop producing viruses. We observed sweeping over-expression of all genes in more than half of chromosome 19 in resistant lines, and karyotypic analyses showed physical rearrangements of this chromosome. Chromosome 19 has an unusual genetic structure whose equivalent is found in all of the sequenced genomes in this ecologically important group of green algae. Public Library of Science 2016-10-27 /pmc/articles/PMC5082852/ /pubmed/27788272 http://dx.doi.org/10.1371/journal.ppat.1005965 Text en © 2016 Yau et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Yau, Sheree Hemon, Claire Derelle, Evelyne Moreau, Hervé Piganeau, Gwenaël Grimsley, Nigel A Viral Immunity Chromosome in the Marine Picoeukaryote, Ostreococcus tauri |
title | A Viral Immunity Chromosome in the Marine Picoeukaryote, Ostreococcus tauri
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title_full | A Viral Immunity Chromosome in the Marine Picoeukaryote, Ostreococcus tauri
|
title_fullStr | A Viral Immunity Chromosome in the Marine Picoeukaryote, Ostreococcus tauri
|
title_full_unstemmed | A Viral Immunity Chromosome in the Marine Picoeukaryote, Ostreococcus tauri
|
title_short | A Viral Immunity Chromosome in the Marine Picoeukaryote, Ostreococcus tauri
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title_sort | viral immunity chromosome in the marine picoeukaryote, ostreococcus tauri |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082852/ https://www.ncbi.nlm.nih.gov/pubmed/27788272 http://dx.doi.org/10.1371/journal.ppat.1005965 |
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