A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation

Amongst the many strategies aiming at inhibiting HIV-1 infection, blocking viral entry has been recently recognized as a very promising approach. Using diverse in vitro models and a broad range of HIV-1 primary patient isolates, we report here that IND02, a type A procyanidin polyphenol extracted fr...

Descripción completa

Detalles Bibliográficos
Autores principales: Connell, Bridgette Janine, Chang, Sui-Yuan, Prakash, Ekambaranellore, Yousfi, Rahima, Mohan, Viswaraman, Posch, Wilfried, Wilflingseder, Doris, Moog, Christiane, Kodama, Eiichi N., Clayette, Pascal, Lortat-Jacob, Hugues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082894/
https://www.ncbi.nlm.nih.gov/pubmed/27788205
http://dx.doi.org/10.1371/journal.pone.0165386

Ejemplares similares

Ejemplares similares